4pdc

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<StructureSection load='4pdc' size='340' side='right'caption='[[4pdc]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='4pdc' size='340' side='right'caption='[[4pdc]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pdc]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cowpx Cowpx] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PDC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pdc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PDC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ffe|4ffe]], [[1mpu|1mpu]], [[1hyr|1hyr]], [[1jsk|1jsk]], [[1kcg|1kcg]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.991&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLRK1, D12S2489E, NKG2D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CPXV018 CDS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10243 COWPX])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdc OCA], [https://pdbe.org/4pdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pdc RCSB], [https://www.ebi.ac.uk/pdbsum/4pdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pdc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pdc OCA], [http://pdbe.org/4pdc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pdc RCSB], [http://www.ebi.ac.uk/pdbsum/4pdc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pdc ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN]] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
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[https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cowpx]]
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[[Category: Cowpox virus]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Structural genomic]]
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[[Category: Fremont DH]]
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[[Category: Fremont, D H]]
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[[Category: Lazear E]]
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[[Category: Lazear, E]]
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[[Category: Nelson CA]]
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[[Category: Nelson, C A]]
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[[Category: Csgid]]
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[[Category: Immune evasion]]
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[[Category: Immune system-viral protein complex]]
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[[Category: Mhc-like fold]]
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[[Category: Nk cell receptor ligand]]
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[[Category: Orthopoxvirus]]
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[[Category: Secreted viral protein]]
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Current revision

Crystal structure of Cowpox virus CPXV018 (OMCP) bound to human NKG2D

PDB ID 4pdc

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