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6if4

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<StructureSection load='6if4' size='340' side='right'caption='[[6if4]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='6if4' size='340' side='right'caption='[[6if4]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6if4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tryb2 Tryb2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IF4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6if4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IF4 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tb927.7.4560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=185431 TRYB2])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.934&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6if4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6if4 OCA], [https://pdbe.org/6if4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6if4 RCSB], [https://www.ebi.ac.uk/pdbsum/6if4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6if4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6if4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6if4 OCA], [http://pdbe.org/6if4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6if4 RCSB], [http://www.ebi.ac.uk/pdbsum/6if4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6if4 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D6XIY7_TRYB2 D6XIY7_TRYB2]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The essential SAS2-related acetyltransferase 1 (Esa1), as a acetyltransferase of MYST family, is indispensable for the cell cycle and transcriptional regulation. The Tudor domain consists of 60 amino acids and belongs to the Royal family, which serves as a module interacting with methylated histone and/or DNA. Although Tudor domain has been widely studied in higher eukaryotes, its structure and function remain unclear in Trypanosoma brucei (T. brucei), a protozoan unicellular parasite causing sleeping sickness in human and nagana in cattle in sub-Saharan Africa. Here, we determined a high-resolution structure of TbEsa1 presumed Tudor domain from T. brucei by X-ray crystallography. TbEsa1 Tudor domain adopts a conserved Tudor-like fold, which is comprised of a five-stranded beta-barrel surrounded by two short alpha-helices. Furthermore, we revealed a non-specific DNA binding pattern of TbEsa1 Tudor domain. However, TbEsa1 Tudor domain showed no methyl-histone binding ability, due to the absence of key aromatic residues forming a conserved aromatic cage.
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Crystal structure of TbEsa1 presumed Tudor domain from Trypanosoma brucei.,Gao J, Ye K, Diwu Y, Xu C, Zhang X, Liao S, Tu X J Struct Biol. 2020 Jan 1;209(1):107406. doi: 10.1016/j.jsb.2019.107406. Epub, 2019 Nov 17. PMID:31747559<ref>PMID:31747559</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6if4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Histone acetyltransferase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tryb2]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Diwu, Y]]
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[[Category: Diwu Y]]
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[[Category: Gao, J]]
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[[Category: Gao J]]
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[[Category: Liao, S]]
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[[Category: Liao S]]
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[[Category: Tu, X]]
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[[Category: Tu X]]
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[[Category: Ye, K]]
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[[Category: Ye K]]
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[[Category: Dna]]
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[[Category: Dna binding protein]]
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[[Category: Methylation]]
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[[Category: Transcription]]
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[[Category: Tudor]]
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Current revision

Crystal structure of Tbtudor

PDB ID 6if4

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