|
|
| (One intermediate revision not shown.) |
| Line 3: |
Line 3: |
| | <StructureSection load='1jpf' size='340' side='right'caption='[[1jpf]], [[Resolution|resolution]] 2.18Å' scene=''> | | <StructureSection load='1jpf' size='340' side='right'caption='[[1jpf]], [[Resolution|resolution]] 2.18Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1jpf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JPF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1jpf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JPF FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fg2|1fg2]], [[1jpg|1jpg]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpf OCA], [https://pdbe.org/1jpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jpf RCSB], [https://www.ebi.ac.uk/pdbsum/1jpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpf ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jpf OCA], [http://pdbe.org/1jpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jpf RCSB], [http://www.ebi.ac.uk/pdbsum/1jpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jpf ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
| Line 31: |
Line 30: |
| | ==See Also== | | ==See Also== |
| | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| - | *[[MHC 3D structures of MHC|MHC 3D structures of MHC]] | + | *[[MHC 3D structures|MHC 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| Line 37: |
Line 36: |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Capitani, G]] | + | [[Category: Capitani G]] |
| - | [[Category: Ciatto, C]] | + | [[Category: Ciatto C]] |
| - | [[Category: Grutter, M G]] | + | [[Category: Grutter MG]] |
| - | [[Category: Pecorari, F]] | + | [[Category: Pecorari F]] |
| - | [[Category: Pluckthun, A]] | + | [[Category: Pluckthun A]] |
| - | [[Category: Tissot, A C]] | + | [[Category: Tissot AC]] |
| - | [[Category: Tschopp, M]] | + | [[Category: Tschopp M]] |
| - | [[Category: Ig fold]]
| + | |
| - | [[Category: Immune system]]
| + | |
| Structural highlights
Function
HA11_MOUSE Involved in the presentation of foreign antigens to the immune system.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Class I major histocompatibility complex (MHC) molecules, which display intracellularly processed peptides on the cell surface for scanning by T-cell receptors (TCRs), are extraordinarily polymorphic. MHC polymorphism is believed to result from natural selection, since individuals heterozygous at the corresponding loci can cope with a larger number of pathogens. Here, we present the crystal structures of the murine MHC molecule H-2D(b) in complex with the peptides gp276 and np396 from the lymphocytic choriomeningitis virus (LCMV), solved at 2.18 A and 2.20 A resolution, respectively. The most prominent feature of H-2D(b) is a hydrophobic ridge that cuts across its antigen-binding site, which is conserved in the L(d)-like family of class I MHC molecules. The comparison with previously solved crystal structures of peptide/H-2D(b) complexes shows that the hydrophobic ridge focuses the conformational variability of the bound peptides in a "hot-spot", which could allow optimal TCR interaction and discrimination. This finding suggests a functional reason for the conservation of this structural element.
Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.,Ciatto C, Tissot AC, Tschopp M, Capitani G, Pecorari F, Pluckthun A, Grutter MG J Mol Biol. 2001 Oct 5;312(5):1059-71. PMID:11580250[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Ciatto C, Tissot AC, Tschopp M, Capitani G, Pecorari F, Pluckthun A, Grutter MG. Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides. J Mol Biol. 2001 Oct 5;312(5):1059-71. PMID:11580250 doi:10.1006/jmbi.2001.5016
|
