1d2e

<table><tr><td colspan='2'>[[1d2e]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D2E FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1efc|1efc]], [[1tui|1tui]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2e OCA], [http://pdbe.org/1d2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1d2e RCSB], [http://www.ebi.ac.uk/pdbsum/1d2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2e ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/EFTU_BOVIN EFTU_BOVIN]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The crystal structure of bovine mitochondrial elongation factor Tu (EF-Tu) in complex with GDP has been determined at a resolution of 1. 94 A. The structure is similar to that of EF-Tu:GDP from Escherichia coli and Thermus aquaticus, but the orientation of the GDP-binding domain 1 is changed relative to domains 2 and 3. Sixteen conserved water molecules common to EF-Tu and other G-proteins in the GDP-binding site are described. These water molecules create a network linking separated parts of the binding pocket. Mitochondrial EF-Tu binds nucleotides less tightly than prokaryotic EF-Tu possibly due to an increased mobility in regions close to the GDP-binding site. The C-terminal extension of mitochondrial EF-Tu has structural similarities with DNA recognising zinc fingers suggesting that the extension may be involved in recognition of RNA.

High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP.,Andersen GR, Thirup S, Spremulli LL, Nyborg J J Mol Biol. 2000 Mar 24;297(2):421-36. PMID:10715211<ref>PMID:10715211</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1d2e" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Andersen, G R]]

[[Category: Nyborg, J]]

[[Category: Spremulli, L L]]

[[Category: Thirup, S]]

[[Category: Rna binding protein]]