6uw6

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'''Unreleased structure'''
 
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The entry 6uw6 is ON HOLD
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==Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc==
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<StructureSection load='6uw6' size='340' side='right'caption='[[6uw6]], [[Resolution|resolution]] 3.66&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6uw6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UW6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.66&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OU:[(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl]+(~{Z})-octadec-9-enoate'>6OU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uw6 OCA], [https://pdbe.org/6uw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uw6 RCSB], [https://www.ebi.ac.uk/pdbsum/6uw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uw6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
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Authors:
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Deng Z]]
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[[Category: Yuan P]]

Current revision

Cryo-EM structure of the human TRPV3 K169A mutant determined in lipid nanodisc

PDB ID 6uw6

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OCA

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