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1kxg

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<StructureSection load='1kxg' size='340' side='right'caption='[[1kxg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1kxg' size='340' side='right'caption='[[1kxg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kxg]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KXG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kxg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxg OCA], [http://pdbe.org/1kxg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kxg RCSB], [http://www.ebi.ac.uk/pdbsum/1kxg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxg ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxg OCA], [https://pdbe.org/1kxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxg RCSB], [https://www.ebi.ac.uk/pdbsum/1kxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arnold, E]]
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[[Category: Arnold E]]
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[[Category: Das, K]]
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[[Category: Das K]]
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[[Category: Dharia, C]]
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[[Category: Dharia C]]
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[[Category: Galperina, O]]
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[[Category: Galperina O]]
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[[Category: Gentz, R]]
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[[Category: Gentz R]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Morris, T S]]
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[[Category: Morris TS]]
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[[Category: Oren, D A]]
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[[Category: Oren DA]]
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[[Category: Volovik, Y]]
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[[Category: Volovik Y]]
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[[Category: Baff]]
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[[Category: Beta-sandwich]]
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[[Category: Cytokine]]
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[[Category: Jellyroll]]
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[[Category: Tall-1]]
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[[Category: Thank]]
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[[Category: Tnf superfamily]]
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[[Category: Ztnf4]]
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Current revision

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

PDB ID 1kxg

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