Peptidyl-tRNA hydrolase
From Proteopedia
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<StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | <StructureSection load='' size='350' side='right' caption='Structure of peptidyl-tRNA hydrolase complex with tRNA CCA acceptor domain (PDB entry [[3vjr]])' scene='55/551222/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability. | + | '''Peptidyl-tRNA hydrolase''' (PTH) is a bacterial enzyme which cleaves peptidyl-tRNA to free peptide and tRNA<ref>PMID:16849786</ref>. PTH catalyzes the reaction in cases of aborted translation for recycling the tRNA for further rounds of protein synthesis. PTH is essential for bacterial viability.rew)]]. |
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| + | See also [[Peptidyl-tRNA hydrolase 2, mitochondrial (Hebrew)]]. | ||
== Structural highlights == | == Structural highlights == | ||
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*Peptidyl-tRNA hydrolase | *Peptidyl-tRNA hydrolase | ||
| + | **[[1q7s]] – hPTH residues 63-179– human<BR /> | ||
**[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | **[[2pth]] – EcPTH – ''Escherichia coli''<BR /> | ||
**[[3ofv]] – EcPTH (mutant)<BR /> | **[[3ofv]] – EcPTH (mutant)<BR /> | ||
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**[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR /> | **[[3v2i]] – PTH – ''Burkholderia thailandesis''<BR /> | ||
**[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR /> | **[[4dhw]], [[4djj]], [[4erx]], [[4fno]], [[4fyj]], [[4jc4]], [[4qaj]] – PaPTH – ''Pseudomonas aeruginosa''<BR /> | ||
| - | **[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[5y98]], [[4lwq]], [[5yl8]], [[5yla]], [[5yn4]], [[5zzv]], [[6a31]], [[6ivv]], [[6iye]], [[6j93]], [[6jgu]], [[6jj1]], [[6jjq]], [[6jkx]], [[6jqt]], [[6jk8]] - AbPTH – ''Acinetobacter baumannii''<BR /> | + | **[[4fop]], [[4fot]], [[4hoy]], [[4iko]], [[4jy7]], [[5y98]], [[4lwq]], [[5yl8]], [[5yla]], [[5yn4]], [[5zzv]], [[6a31]], [[6ivv]], [[6iye]], [[6j93]], [[6jgu]], [[6jj1]], [[6jjq]], [[6jkx]], [[6jqt]], [[6jk8]], [[6kl8]], [[6lso]], [[6lsp]], [[7csn]] - AbPTH – ''Acinetobacter baumannii''<BR /> |
**[[4olj]], [[6ix6]] – AbPTH (mutant)<BR /> | **[[4olj]], [[6ix6]] – AbPTH (mutant)<BR /> | ||
**[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | **[[4p7b]] – PTH – ''Salmonella enterica''<BR /> | ||
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**[[4yly]] – PTH – ''Streptococcus aureus''<BR /> | **[[4yly]] – PTH – ''Streptococcus aureus''<BR /> | ||
**[[5zx8]] – PTH – ''Thermus thermophilus''<BR /> | **[[5zx8]] – PTH – ''Thermus thermophilus''<BR /> | ||
| + | **[[7brd]] – PTH – ''Klebsiella pneumoniae''<BR /> | ||
*Peptidyl-tRNA hydrolase complex | *Peptidyl-tRNA hydrolase complex | ||
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**[[4jx9]] – AbPTH + uridine<BR /> | **[[4jx9]] – AbPTH + uridine<BR /> | ||
**[[4qbk]] – PaPTH + adenosine derivative<BR /> | **[[4qbk]] – PaPTH + adenosine derivative<BR /> | ||
| + | **[[8axp]] – PTH + thyazole derivative – ''Neisseria gonorrhoeae''<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of peptidyl-tRNA hydrolase
Updated on 05-January-2025
References
- ↑ Das G, Varshney U. Peptidyl-tRNA hydrolase and its critical role in protein biosynthesis. Microbiology. 2006 Aug;152(Pt 8):2191-5. PMID:16849786 doi:http://dx.doi.org/10.1099/mic.0.29024-0
- ↑ Ito K, Murakami R, Mochizuki M, Qi H, Shimizu Y, Miura KI, Ueda T, Uchiumi T. Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase. Nucleic Acids Res. 2012 Aug 25. PMID:22923517 doi:10.1093/nar/gks790
