6mg0

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<StructureSection load='6mg0' size='340' side='right'caption='[[6mg0]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
<StructureSection load='6mg0' size='340' side='right'caption='[[6mg0]], [[Resolution|resolution]] 6.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6mg0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6mg0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MG0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DG9:5-({[(2R,3R)-3-AMINO-2-{[2-({N-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-{[OXIDO(OXO)PHOSPHONIO]OXY}BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-4-METHYLPENTYL]SULFONYL}AMINO)-5-DEOXYADENOSINE'>DG9</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg0 OCA], [http://pdbe.org/6mg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg0 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg0 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DG9:5-({[(2R,3R)-3-AMINO-2-{[2-({N-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-{[OXIDO(OXO)PHOSPHONIO]OXY}BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]SULFANYL}-4-METHYLPENTYL]SULFONYL}AMINO)-5-DEOXYADENOSINE'>DG9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg0 OCA], [https://pdbe.org/6mg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mg0 RCSB], [https://www.ebi.ac.uk/pdbsum/6mg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA]] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
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[https://www.uniprot.org/uniprot/LGRA_BREPA LGRA_BREPA] Activates valine (or leucine, but much less frequently), and then glycine and catalyzes the formation of the peptide bond in the first step of peptide synthesis. This enzyme may also play a role in N-formylation of the first amino acid residue in the synthesized dipeptide.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mg0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mg0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Linear gramicidin synthase|Linear gramicidin synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brevibacillus parabrevis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Eivaskhani, M]]
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[[Category: Eivaskhani M]]
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[[Category: Harb, I]]
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[[Category: Harb I]]
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[[Category: Reimer, J M]]
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[[Category: Reimer JM]]
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[[Category: Schmeing, T M]]
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[[Category: Schmeing TM]]
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[[Category: Enzyme]]
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[[Category: Ligase]]
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[[Category: Linear gramicidin]]
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[[Category: Natural product]]
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[[Category: Nonribosomal peptide synthetase]]
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[[Category: Nrp]]
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[[Category: Tailoring domain]]
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Current revision

Crystal structure of a 5-domain construct of LgrA in the thiolation state

PDB ID 6mg0

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