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6q7u

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<StructureSection load='6q7u' size='340' side='right'caption='[[6q7u]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
<StructureSection load='6q7u' size='340' side='right'caption='[[6q7u]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6q7u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q7U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q7U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6q7u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q7U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q7U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HLH:2-heptyl-1~{H}-quinolin-4-one'>HLH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.14&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q7u OCA], [http://pdbe.org/6q7u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q7u RCSB], [http://www.ebi.ac.uk/pdbsum/6q7u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q7u ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HLH:2-heptyl-1~{H}-quinolin-4-one'>HLH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q7u OCA], [https://pdbe.org/6q7u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q7u RCSB], [https://www.ebi.ac.uk/pdbsum/6q7u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q7u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MVFR_PSEAE MVFR_PSEAE]] Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon (PubMed:11724939, PubMed:27678057, PubMed:17083468). At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space (PubMed:11724939).<ref>PMID:11724939</ref> <ref>PMID:17083468</ref> <ref>PMID:27678057</ref>
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[https://www.uniprot.org/uniprot/MVFR_PSEAE MVFR_PSEAE] Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon (PubMed:11724939, PubMed:27678057, PubMed:17083468). At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space (PubMed:11724939).<ref>PMID:11724939</ref> <ref>PMID:17083468</ref> <ref>PMID:27678057</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6q7u" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6q7u" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blankenfeldt, W]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Witzgall, F]]
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[[Category: Blankenfeldt W]]
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[[Category: Xu, N]]
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[[Category: Witzgall F]]
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[[Category: Dna binding protein]]
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[[Category: Xu N]]
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[[Category: Lttr]]
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[[Category: Lysr-type transcriptional regulator]]
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[[Category: Pseudomonas quinolone signaling system]]
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[[Category: Quorum sensing]]
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Current revision

Crystal structure of PqsR (MvfR) ligand-binding domain in complex with HHQ

PDB ID 6q7u

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