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5ceg

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<StructureSection load='5ceg' size='340' side='right'caption='[[5ceg]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
<StructureSection load='5ceg' size='340' side='right'caption='[[5ceg]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ceg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesow Mesow]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ceg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_opportunistum_WSM2075 Mesorhizobium opportunistum WSM2075]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mesop_5599 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=536019 MESOW]), Mesop_5598 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=536019 MESOW])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ceg OCA], [http://pdbe.org/5ceg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ceg RCSB], [http://www.ebi.ac.uk/pdbsum/5ceg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ceg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ceg OCA], [https://pdbe.org/5ceg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ceg RCSB], [https://www.ebi.ac.uk/pdbsum/5ceg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ceg ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/F7YBW8_MESOW F7YBW8_MESOW]
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Interacting proteins typically coevolve, and the identification of coevolving amino acids can pinpoint residues required for interaction specificity. This approach often assumes that an interface-disrupting mutation in one protein drives selection of a compensatory mutation in its partner during evolution. However, this model requires a non-functional intermediate state prior to the compensatory change. Alternatively, a mutation in one protein could first broaden its specificity, allowing changes in its partner, followed by a specificity-restricting mutation. Using bacterial toxin-antitoxin systems, we demonstrate the plausibility of this second, promiscuity-based model. By screening large libraries of interface mutants, we show that toxins and antitoxins with high specificity are frequently connected in sequence space to more promiscuous variants that can serve as intermediates during a reprogramming of interaction specificity. We propose that the abundance of promiscuous variants promotes the expansion and diversification of toxin-antitoxin systems and other paralogous protein families during evolution.
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Evolving new protein-protein interaction specificity through promiscuous intermediates.,Aakre CD, Herrou J, Phung TN, Perchuk BS, Crosson S, Laub MT Cell. 2015 Oct 22;163(3):594-606. doi: 10.1016/j.cell.2015.09.055. Epub 2015 Oct , 17. PMID:26478181<ref>PMID:26478181</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ceg" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mesow]]
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[[Category: Mesorhizobium opportunistum WSM2075]]
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[[Category: Aakre, C D]]
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[[Category: Aakre CD]]
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[[Category: Crosson, S]]
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[[Category: Crosson S]]
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[[Category: Herrou, J]]
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[[Category: Herrou J]]
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[[Category: Laub, M T]]
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[[Category: Laub MT]]
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[[Category: Toxin]]
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[[Category: Toxin anti-toxin]]
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Current revision

X-ray structure of toxin/anti-toxin complex from Mesorhizobium opportunistum

PDB ID 5ceg

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