5kci

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<StructureSection load='5kci' size='340' side='right'caption='[[5kci]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='5kci' size='340' side='right'caption='[[5kci]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kci]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KCI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KCI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.833&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YPL067C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kci OCA], [http://pdbe.org/5kci PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kci RCSB], [http://www.ebi.ac.uk/pdbsum/5kci PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kci ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kci OCA], [https://pdbe.org/5kci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kci RCSB], [https://www.ebi.ac.uk/pdbsum/5kci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kci ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/YP067_YEAST YP067_YEAST]
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We show here that computer game players can build high-quality crystal structures. Introduction of a new feature into the computer game Foldit allows players to build and real-space refine structures into electron density maps. To assess the usefulness of this feature, we held a crystallographic model-building competition between trained crystallographers, undergraduate students, Foldit players and automatic model-building algorithms. After removal of disordered residues, a team of Foldit players achieved the most accurate structure. Analysing the target protein of the competition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prevention of amyloid toxicity. From this study, we conclude that crystallographers can utilize crowdsourcing to interpret electron density information and to produce structure solutions of the highest quality.
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Determining crystal structures through crowdsourcing and coursework.,Horowitz S, Koepnick B, Martin R, Tymieniecki A, Winburn AA, Cooper S, Flatten J, Rogawski DS, Koropatkin NM, Hailu TT, Jain N, Koldewey P, Ahlstrom LS, Chapman MR, Sikkema AP, Skiba MA, Maloney FP, Beinlich FR, Popovic Z, Baker D, Khatib F, Bardwell JC Nat Commun. 2016 Sep 16;7:12549. doi: 10.1038/ncomms12549. PMID:27633552<ref>PMID:27633552</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5kci" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baker, D]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Bardwell, J C.A]]
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[[Category: Baker D]]
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[[Category: Beinlich, F R.M]]
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[[Category: Bardwell JCA]]
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[[Category: Cooper, S]]
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[[Category: Beinlich FRM]]
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[[Category: Flatten, J]]
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[[Category: Cooper S]]
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[[Category: Horowitz, S]]
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[[Category: Flatten J]]
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[[Category: Khatib, F]]
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[[Category: Horowitz S]]
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[[Category: Koepnick, B]]
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[[Category: Khatib F]]
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[[Category: Koropatkin, N M]]
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[[Category: Koepnick B]]
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[[Category: Martin, R M]]
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[[Category: Koropatkin NM]]
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[[Category: Players, F]]
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[[Category: Martin RM]]
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[[Category: Popovic, Z]]
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[[Category: Players F]]
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[[Category: Rogawski, D S]]
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[[Category: Popovic Z]]
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[[Category: Students, U M]]
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[[Category: Rogawski DS]]
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[[Category: Histidine triad amyloid toxicity]]
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[[Category: Students UM]]
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[[Category: Unknown function]]
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Current revision

Crystal Structure of HTC1

PDB ID 5kci

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