6j55

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<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
<StructureSection load='6j55' size='340' side='right'caption='[[6j55]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Acaca Acaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J55 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6j55]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J55 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.330005&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j55 OCA], [http://pdbe.org/6j55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j55 RCSB], [http://www.ebi.ac.uk/pdbsum/6j55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j55 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j55 OCA], [https://pdbe.org/6j55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j55 RCSB], [https://www.ebi.ac.uk/pdbsum/6j55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j55 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
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[https://www.uniprot.org/uniprot/Q5IZD9_ACACA Q5IZD9_ACACA] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.[RuleBase:RU000414]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The iron superoxide dismutase found in the pathogenic amoeba Acanthamoeba castellanii (AcFeSOD) may play essential roles in the survival of the parasite, not only by protecting it from endogenous oxidative stress but also by detoxifying oxidative killing of the parasite by host immune effector cells. The AcFeSOD protein was expressed in a stable form using an Escherichia coli expression system and was crystallized by the microbatch and hanging-drop vapour-diffusion methods. The structure was determined to 2.33 A resolution from a single AcFeSOD crystal. The crystal belonged to the hexagonal space group P61 and contained 12 molecules forming three tetramers in the asymmetric unit, with an iron ion bound in each molecule. Structural comparisons and sequence alignment of AcFeSOD with other FeSODs showed a well conserved overall fold and conserved active-site residues with subtle differences.
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Crystal structure of an iron superoxide dismutase from the pathogenic amoeba Acanthamoeba castellanii.,Dao O, Asaithambi K, Na BK, Lee KH Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):480-488. doi:, 10.1107/S2053230X19008112. Epub 2019 Jun 26. PMID:31282867<ref>PMID:31282867</ref>
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==See Also==
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6j55" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acaca]]
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[[Category: Acanthamoeba castellanii]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Superoxide dismutase]]
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[[Category: Asaithambi K]]
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[[Category: Asaithambi, K]]
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[[Category: Dao TO]]
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[[Category: Dao, T O]]
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[[Category: Lee KH]]
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[[Category: Lee, K H]]
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[[Category: Na BK]]
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[[Category: Na, B K]]
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[[Category: Acanthamoeba castellanii]]
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[[Category: Iron superoxide dismutase]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of an iron superoxide dismutate (FeSOD) from a pathogenic Acanthamoeba castellanii

PDB ID 6j55

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