153d

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[[Image:153d.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE==
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The line below this paragraph, containing "STRUCTURE_153d", creates the "Structure Box" on the page.
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<StructureSection load='153d' size='340' side='right'caption='[[153d]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[153d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=153D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=153D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene></td></tr>
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{{STRUCTURE_153d| PDB=153d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=153d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=153d OCA], [https://pdbe.org/153d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=153d RCSB], [https://www.ebi.ac.uk/pdbsum/153d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=153d ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Berman HM]]
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The crystal structure of the synthetic deoxydodecamer d(CGAGAATTC(O6Me)GCG)2 has been determined and refined to an R-factor of 16.9% with data up to 2.9-A resolution. This sequence contains two mismatched base pairs between O6-methylguanine and adenine with the arrangement A(syn).(O6-Me)G(anti) which differs from the geometry observed in solution by NMR. The intermolecular arrangement is equivalent to the other isomorphous deoxydodecamers. However, the weakening of some significant crystal packing contacts was observed and related to the effect of stacking between the mispaired adenine and the adjacent guanine in the sequence. The structure is highly hydrated, with a total of 49 solvent molecules located. The methyl group and the mismatched base-pair geometry locally disrupt the B-DNA-type solvent network with two solvent molecules found close to the N1 and N6 of the mispaired adenine.
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[[Category: Gaffney B]]
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[[Category: Ginell SL]]
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==About this Structure==
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[[Category: Jones R]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=153D OCA].
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[[Category: Vojtechovsky J]]
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==Reference==
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Crystal structure of a mispaired dodecamer, d(CGAGAATTC(O6Me)GCG)2, containing a carcinogenic O6-methylguanine., Ginell SL, Vojtechovsky J, Gaffney B, Jones R, Berman HM, Biochemistry. 1994 Mar 29;33(12):3487-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8142345 8142345]
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[[Category: Berman, H M.]]
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[[Category: Gaffney, B.]]
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[[Category: Ginell, S L.]]
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[[Category: Jones, R.]]
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[[Category: Vojtechovsky, J.]]
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[[Category: B-dna]]
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[[Category: Double helix]]
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[[Category: Mismatched]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:31:00 2008''
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Current revision

CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE

PDB ID 153d

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