1o9y

From Proteopedia

(Difference between revisions)

Current revision

Crystal structure of the C-terminal domain of the HrcQb protein from Pseudomonas syringae pv. phaseolicola

Structural highlights

1o9y is a 4 chain structure with sequence from Pseudomonas syringae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.29Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HRCQB_PSESH Component of the type III secretion system, which is required for effector protein delivery, parasitism, and pathogenicity. Probably participates in the formation of a C-ring-like assembly along with HrcQa.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in mammals, and localized lesions, systemic wilting, and blights in plants. In addition, type III secretion systems are also required for biogenesis of the bacterial flagellum. The HrcQ(B) protein, a component of the secretion apparatus of Pseudomonas syringae with homologues in all type III systems, has a variable N-terminal and a conserved C-terminal domain (HrcQ(B)-C). Here, we report the crystal structure of HrcQ(B)-C and show that this domain retains the ability of the full-length protein to interact with other type III components. A 3D analysis of sequence conservation patterns reveals two clusters of residues potentially involved in protein-protein interactions. Based on the analogies between HrcQ(B) and its flagellum homologues, we propose that HrcQ(B)-C participates in the formation of a C-ring-like assembly.

Structure of HrcQB-C, a conserved component of the bacterial type III secretion systems.,Fadouloglou VE, Tampakaki AP, Glykos NM, Bastaki MN, Hadden JM, Phillips SE, Panopoulos NJ, Kokkinidis M Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):70-5. Epub 2003 Dec 23. PMID:14694203^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Fadouloglou VE, Tampakaki AP, Glykos NM, Bastaki MN, Hadden JM, Phillips SE, Panopoulos NJ, Kokkinidis M. Structure of HrcQB-C, a conserved component of the bacterial type III secretion systems. Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):70-5. Epub 2003 Dec 23. PMID:14694203 doi:http://dx.doi.org/10.1073/pnas.0304579101

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o9y"

Categories: Large Structures | Pseudomonas syringae | Fadouloglou VE | Kokkinidis M

@@ Line 3: / Line 3: @@
 <StructureSection load='1o9y' size='340' side='right'caption='[[1o9y]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1o9y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O9Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1o9y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O9Y FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9y OCA], [http://pdbe.org/1o9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1o9y RCSB], [http://www.ebi.ac.uk/pdbsum/1o9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1o9y ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9y OCA], [https://pdbe.org/1o9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o9y RCSB], [https://www.ebi.ac.uk/pdbsum/1o9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o9y ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HRCQB_PSESH HRCQB_PSESH] Component of the type III secretion system, which is required for effector protein delivery, parasitism, and pathogenicity. Probably participates in the formation of a C-ring-like assembly along with HrcQa.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 11: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o9/1o9y_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 29: / Line 32: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 19310]]
 [[Category: Large Structures]]
-[[Category: Fadouloglou, V E]]
+[[Category: Pseudomonas syringae]]
-[[Category: Kokkinidis, M]]
+[[Category: Fadouloglou VE]]
-[[Category: Hrp]]
+[[Category: Kokkinidis M]]
-[[Category: Phytopathogenicity]]
-[[Category: Secretory protein]]
-[[Category: Structural protein]]
-[[Category: Type iii secretion system]]

1o9y

From Proteopedia

Current revision

Crystal structure of the C-terminal domain of the HrcQb protein from Pseudomonas syringae pv. phaseolicola

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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