1ogq

From Proteopedia

(Difference between revisions)

Current revision

The crystal structure of PGIP (polygalacturonase inhibiting protein), a leucine rich repeat protein involved in plant defense

Structural highlights

1ogq is a 1 chain structure with sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PGIP2_PHAVU Inhibitor of fungal polygalacturonase. It is an important factor for plant resistance to phytopathogenic fungi. Inhibits all polygalacturonases (PG) tested, with the exception of PG from F.oxysporum which was only inhibited at 60%.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Polygalacturonase-inhibiting proteins (PGIPs) are plant cell wall proteins that protect plants from fungal invasion. They interact with endopolygalacturonases secreted by phytopathogenic fungi, inhibit their enzymatic activity, and favor the accumulation of oligogalacturonides, which activate plant defense responses. PGIPs are members of the leucine-rich repeat (LRR) protein family that in plants play crucial roles in development, defense against pathogens, and recognition of beneficial microbes. Here we report the crystal structure at 1.7-A resolution of a PGIP from Phaseolus vulgaris. The structure is characterized by the presence of two beta-sheets instead of the single one originally predicted by modeling studies. The structure also reveals a negatively charged surface on the LRR concave face, likely involved in binding polygalacturonases. The structural information on PGIP provides a basis for designing more efficient inhibitors for plant protection.

The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense.,Di Matteo A, Federici L, Mattei B, Salvi G, Johnson KA, Savino C, De Lorenzo G, Tsernoglou D, Cervone F Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10124-8. Epub 2003 Aug 6. PMID:12904578^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Di Matteo A, Federici L, Mattei B, Salvi G, Johnson KA, Savino C, De Lorenzo G, Tsernoglou D, Cervone F. The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10124-8. Epub 2003 Aug 6. PMID:12904578 doi:http://dx.doi.org/10.1073/pnas.1733690100

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ogq"

@@ Line 3: / Line 3: @@
 <StructureSection load='1ogq' size='340' side='right'caption='[[1ogq]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ogq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/French_bean French bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OGQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ogq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phaseolus_vulgaris Phaseolus vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OGQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ogq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ogq OCA], [http://pdbe.org/1ogq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ogq RCSB], [http://www.ebi.ac.uk/pdbsum/1ogq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ogq ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ogq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ogq OCA], [https://pdbe.org/1ogq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ogq RCSB], [https://www.ebi.ac.uk/pdbsum/1ogq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ogq ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/PGIP2_PHAVU PGIP2_PHAVU]] Inhibitor of fungal polygalacturonase. It is an important factor for plant resistance to phytopathogenic fungi. Inhibits all polygalacturonases (PG) tested, with the exception of PG from F.oxysporum which was only inhibited at 60%.
+[https://www.uniprot.org/uniprot/PGIP2_PHAVU PGIP2_PHAVU] Inhibitor of fungal polygalacturonase. It is an important factor for plant resistance to phytopathogenic fungi. Inhibits all polygalacturonases (PG) tested, with the exception of PG from F.oxysporum which was only inhibited at 60%.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 14: / Line 15: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/og/1ogq_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: French bean]]
 [[Category: Large Structures]]
-[[Category: Cervone, F]]
+[[Category: Phaseolus vulgaris]]
-[[Category: Federici, L]]
+[[Category: Cervone F]]
-[[Category: Johnson, K A]]
+[[Category: De Lorenzo G]]
-[[Category: Lorenzo, G De]]
+[[Category: Di Matteo A]]
-[[Category: Mattei, B]]
+[[Category: Federici L]]
-[[Category: Matteo, A Di]]
+[[Category: Johnson KA]]
-[[Category: Salvi, G]]
+[[Category: Mattei B]]
-[[Category: Savino, C]]
+[[Category: Salvi G]]
-[[Category: Tsernoglou, D]]
+[[Category: Savino C]]
-[[Category: Inhibitor]]
+[[Category: Tsernoglou D]]
-[[Category: Polygalacturonase inhibiting protein]]

1ogq

From Proteopedia

Current revision

The crystal structure of PGIP (polygalacturonase inhibiting protein), a leucine rich repeat protein involved in plant defense

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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