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| | <StructureSection load='1ocw' size='340' side='right'caption='[[1ocw]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='1ocw' size='340' side='right'caption='[[1ocw]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1ocw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OCW FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1ocw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OCW FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1oaq|1oaq]], [[1oar|1oar]], [[1oau|1oau]], [[1oax|1oax]], [[1oay|1oay]], [[1oaz|1oaz]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ocw OCA], [http://pdbe.org/1ocw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ocw RCSB], [http://www.ebi.ac.uk/pdbsum/1ocw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ocw ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ocw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ocw OCA], [https://pdbe.org/1ocw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ocw RCSB], [https://www.ebi.ac.uk/pdbsum/1ocw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ocw ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/LV1B_MOUSE LV1B_MOUSE] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: James, L C]] | + | [[Category: James LC]] |
| - | [[Category: Roversi, P]] | + | [[Category: Roversi P]] |
| - | [[Category: Tawfik, D]] | + | [[Category: Tawfik D]] |
| - | [[Category: Allergy]]
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| - | [[Category: Antibody]]
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| - | [[Category: Conformational diversity]]
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| - | [[Category: Immune system]]
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| - | [[Category: Multispecificity]]
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| Structural highlights
Function
LV1B_MOUSE
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
Antibody multispecificity mediated by conformational diversity.,James LC, Roversi P, Tawfik DS Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ James LC, Roversi P, Tawfik DS. Antibody multispecificity mediated by conformational diversity. Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298 doi:10.1126/science.1079731
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