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6ux6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cruzain covalently bound by a vinylsulfone compound== | |
| + | <StructureSection load='6ux6' size='340' side='right'caption='[[6ux6]], [[Resolution|resolution]] 1.94Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ux6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UX6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TM8:Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-phenyl-4-(phenylsulfonyl)butan-2-yl]-L-phenylalaninamide'>TM8</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ux6 OCA], [https://pdbe.org/6ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/6ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ux6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. | ||
| - | + | ==See Also== | |
| - | + | *[[Cruzain|Cruzain]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Trypanosoma cruzi]] |
| - | [[Category: | + | [[Category: Chenna BC]] |
| - | [[Category: | + | [[Category: Meek TD]] |
| - | [[Category: | + | [[Category: Sacchettini JC]] |
| + | [[Category: Tang S]] | ||
| + | [[Category: Zhai X]] | ||
Current revision
Cruzain covalently bound by a vinylsulfone compound
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