183d

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[[Image:183d.gif|left|200px]]
 
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==X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE==
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The line below this paragraph, containing "STRUCTURE_183d", creates the "Structure Box" on the page.
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<StructureSection load='183d' size='340' side='right'caption='[[183d]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[183d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=183D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=183D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene></td></tr>
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{{STRUCTURE_183d| PDB=183d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=183d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=183d OCA], [https://pdbe.org/183d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=183d RCSB], [https://www.ebi.ac.uk/pdbsum/183d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=183d ProSAT]</span></td></tr>
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</table>
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'''X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Essigmann JM]]
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We have determined the x-ray structure of a DNA fragment containing 7,8-dihydro-8-oxoguanine (G(O)). The structure of the duplex form of d(CCAGOCGCTGG) has been determined to 1.6-A resolution. The results demonstrate that GO forms Watson-Crick base pairs with the opposite C and that G(O) is in the anti conformation. Structural perturbations induced by C.G(O)anti base pairs are subtle. The structure allows us to identify probable elements by which the DNA repair protein MutM recognizes its substrates. Hydrogen bond donors/acceptors within the major groove are the most likely element. In that groove, the pattern of hydrogen-bond donors/acceptors of C.G(O)anti is unique. Additional structural analysis indicates that conversion of G to G(O) would not significantly influence the glycosidic torsion preference of the nucleoside. There is no steric interaction of the 8-oxygen of G(O) with the phospho-deoxyribose backbone.
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[[Category: Lipscomb LA]]
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[[Category: Miller EM]]
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==About this Structure==
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[[Category: Morningstar ML]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=183D OCA].
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[[Category: Peek ME]]
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[[Category: Rich A]]
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==Reference==
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[[Category: Verghis SM]]
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X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine., Lipscomb LA, Peek ME, Morningstar ML, Verghis SM, Miller EM, Rich A, Essigmann JM, Williams LD, Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):719-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7846041 7846041]
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[[Category: Williams LD]]
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[[Category: Essigmann, J M.]]
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[[Category: Lipscomb, L A.]]
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[[Category: Miller, E M.]]
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[[Category: Morningstar, M L.]]
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[[Category: Peek, M E.]]
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[[Category: Rich, A.]]
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[[Category: Verghis, S M.]]
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[[Category: Williams, L D.]]
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[[Category: B-dna]]
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[[Category: Double helix]]
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[[Category: Modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:34:10 2008''
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Current revision

X-RAY STRUCTURE OF A DNA DECAMER CONTAINING 7, 8-DIHYDRO-8-OXOGUANINE

PDB ID 183d

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