6urg

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==Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex==
==Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex==
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<StructureSection load='6urg' size='340' side='right'caption='[[6urg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<SX load='6urg' size='340' side='right' viewer='molstar' caption='[[6urg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6urg]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6URG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6urg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6URG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6URG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6uro|6uro]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6urg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urg OCA], [http://pdbe.org/6urg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6urg RCSB], [http://www.ebi.ac.uk/pdbsum/6urg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6urg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6urg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6urg OCA], [https://pdbe.org/6urg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6urg RCSB], [https://www.ebi.ac.uk/pdbsum/6urg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6urg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CPSF2_HUMAN CPSF2_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing.<ref>PMID:14749727</ref> <ref>PMID:18688255</ref> [[http://www.uniprot.org/uniprot/CPSF1_HUMAN CPSF1_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.<ref>PMID:14749727</ref> [[http://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN]] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref> [[http://www.uniprot.org/uniprot/WDR33_HUMAN WDR33_HUMAN]] Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.<ref>PMID:19217410</ref>
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[https://www.uniprot.org/uniprot/CPSF4_HUMAN CPSF4_HUMAN] Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).<ref>PMID:9224719</ref> <ref>PMID:14749727</ref>
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sun, Y]]
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[[Category: Sun Y]]
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[[Category: Tong, L]]
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[[Category: Tong L]]
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[[Category: Walz, T]]
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[[Category: Walz T]]
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[[Category: Zhang, Y]]
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[[Category: Zhang Y]]
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[[Category: Cpsf100]]
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[[Category: Mpsf]]
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[[Category: Pre-mrna 3'-end processing]]
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[[Category: Protein binding]]
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Current revision

Cryo-EM structure of human CPSF160-WDR33-CPSF30-CPSF100 PIM complex

6urg, resolution 3.00Å

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