191d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:26, 7 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:191d.jpg|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)==
-
The line below this paragraph, containing "STRUCTURE_191d", creates the "Structure Box" on the page.
+
<StructureSection load='191d' size='340' side='right'caption='[[191d]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[191d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=191D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=191D FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_191d| PDB=191d | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=191d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=191d OCA], [https://pdbe.org/191d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=191d RCSB], [https://www.ebi.ac.uk/pdbsum/191d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=191d ProSAT]</span></td></tr>
-
 
+
</table>
-
'''CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Overview==
+
[[Category: Berger I]]
-
The crystal structure of d(C3T), solved at 1.4 A resolution, reveals that the molecule forms a four-stranded intercalated complex. It consists of two parallel-stranded duplexes, each of which is held together by cytosine-protonated cytosine base pairs. The two duplexes are intercalated with each other and have opposite strand orientation. The molecule has a flat, lath-like appearance, and the covalently bonded cytosines have a slow right-handed twist of 17.1 degrees. However, there is considerable asymmetry. On one of the flat sides, the phosphate groups are rotated away from the center of the molecule. They are held in this orientation by bridging water molecules that bind the NH of cytosine and a phosphate group of an opposite chain. There is also considerable microheterogeneity in the structure. The cytosine hemiprotonation occurs even at pH 7 where stable crystals form.
+
[[Category: Kang C]]
-
 
+
[[Category: Lockshin C]]
-
==About this Structure==
+
[[Category: Moyzis R]]
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=191D OCA].
+
[[Category: Ratliff R]]
-
 
+
[[Category: Rich A]]
-
==Reference==
+
-
Crystal structure of intercalated four-stranded d(C3T) at 1.4 A resolution., Kang CH, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11636-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7972115 7972115]
+
-
[[Category: Berger, I.]]
+
-
[[Category: Kang, C.]]
+
-
[[Category: Lockshin, C.]]
+
-
[[Category: Moyzis, R.]]
+
-
[[Category: Ratliff, R.]]
+
-
[[Category: Rich, A.]]
+
-
[[Category: Base intercalated]]
+
-
[[Category: Mismatched]]
+
-
[[Category: Parallel-stranded tetraplex]]
+
-
[[Category: Quadruple helix]]
+
-
[[Category: U-dna]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:35:02 2008''
+

Current revision

CRYSTAL STRUCTURE OF INTERCALATED FOUR-STRANDED D(C3T)

PDB ID 191d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/191d"
Personal tools