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6b73

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Current revision (14:33, 4 October 2023) (edit) (undo)
 
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<StructureSection load='6b73' size='340' side='right'caption='[[6b73]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='6b73' size='340' side='right'caption='[[6b73]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b73]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B73 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B73 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=CVV:N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide'>CVV</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OPRK1, OPRK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=CVV:N-[(5alpha,6beta)-17-(cyclopropylmethyl)-3-hydroxy-7,8-didehydro-4,5-epoxymorphinan-6-yl]-3-iodobenzamide'>CVV</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b73 OCA], [http://pdbe.org/6b73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b73 RCSB], [http://www.ebi.ac.uk/pdbsum/6b73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b73 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b73 OCA], [https://pdbe.org/6b73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b73 RCSB], [https://www.ebi.ac.uk/pdbsum/6b73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b73 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6b73" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6b73" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Camelus glama]]
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[[Category: Homo sapiens]]
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[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carroll, I F]]
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[[Category: Carroll IF]]
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[[Category: Che, T]]
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[[Category: Che T]]
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[[Category: Cherezov, V]]
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[[Category: Cherezov V]]
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[[Category: Han, G W]]
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[[Category: Han GW]]
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[[Category: Huang, X P]]
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[[Category: Huang XP]]
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[[Category: Katritch, V]]
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[[Category: Katritch V]]
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[[Category: Kormos, C]]
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[[Category: Kormos C]]
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[[Category: Krumm, B E]]
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[[Category: Krumm BE]]
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[[Category: Lee, M Y]]
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[[Category: Lee MY]]
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[[Category: Majumdar, S]]
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[[Category: Majumdar S]]
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[[Category: McCorvy, J D]]
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[[Category: McCorvy JD]]
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[[Category: Mosier, P D]]
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[[Category: Mosier PD]]
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[[Category: Pardon, E]]
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[[Category: Pardon E]]
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[[Category: Pasternak, G W]]
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[[Category: Pasternak GW]]
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[[Category: Roth, B L]]
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[[Category: Roth BL]]
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[[Category: Stevens, R C]]
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[[Category: Stevens RC]]
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[[Category: Steyaert, J]]
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[[Category: Steyaert J]]
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[[Category: Strachan, R T]]
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[[Category: Strachan RT]]
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[[Category: Tribo, A R]]
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[[Category: Tribo AR]]
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[[Category: Uprety, R]]
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[[Category: Uprety R]]
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[[Category: Vardy, E]]
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[[Category: Vardy E]]
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[[Category: Wacker, D]]
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[[Category: Wacker D]]
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[[Category: Wang, S]]
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[[Category: Wang S]]
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[[Category: Zaidi, S A]]
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[[Category: Zaidi SA]]
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[[Category: Active state]]
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[[Category: Addiction]]
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[[Category: Gpcr]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Membrane protein-agonist complex]]
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[[Category: Morphinan]]
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[[Category: Nanobody]]
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[[Category: Opioid receptor]]
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[[Category: Structure-function]]
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Current revision

Crystal Structure of a nanobody-stabilized active state of the kappa-opioid receptor

PDB ID 6b73

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