6noj
From Proteopedia
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<StructureSection load='6noj' size='340' side='right'caption='[[6noj]], [[Resolution|resolution]] 2.33Å' scene=''> | <StructureSection load='6noj' size='340' side='right'caption='[[6noj]], [[Resolution|resolution]] 2.33Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6noj]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6noj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NOJ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KW7:methyl+3-azanyl-4-(2-fluorophenyl)-1~{H}-pyrrole-2-carboxylate'>KW7</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6noj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6noj OCA], [https://pdbe.org/6noj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6noj RCSB], [https://www.ebi.ac.uk/pdbsum/6noj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6noj ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Perry | + | [[Category: Perry E]] |
| - | [[Category: Zhao | + | [[Category: Zhao B]] |
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Current revision
PD-L1 IgV domain V76T with fragment
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