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| | <StructureSection load='1pgr' size='340' side='right'caption='[[1pgr]], [[Resolution|resolution]] 3.50Å' scene=''> | | <StructureSection load='1pgr' size='340' side='right'caption='[[1pgr]], [[Resolution|resolution]] 3.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1pgr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PGR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1pgr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PGR FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pgr OCA], [http://pdbe.org/1pgr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pgr RCSB], [http://www.ebi.ac.uk/pdbsum/1pgr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pgr ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> |
| | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pgr OCA], [https://pdbe.org/1pgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pgr RCSB], [https://www.ebi.ac.uk/pdbsum/1pgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pgr ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN]] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. [[http://www.uniprot.org/uniprot/CSF3R_MOUSE CSF3R_MOUSE]] Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface. | + | [https://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Aritomi, M]] | + | [[Category: Aritomi M]] |
| - | [[Category: Kunishima, N]] | + | [[Category: Kunishima N]] |
| - | [[Category: Kuroki, R]] | + | [[Category: Kuroki R]] |
| - | [[Category: Morikawa, K]] | + | [[Category: Morikawa K]] |
| - | [[Category: Okamoto, T]] | + | [[Category: Okamoto T]] |
| - | [[Category: Ota, Y]] | + | [[Category: Ota Y]] |
| - | [[Category: Class1 cytokine]]
| + | |
| - | [[Category: Cytokine]]
| + | |
| - | [[Category: Hematopoietic receptor]]
| + | |
| - | [[Category: Signal transduction]]
| + | |
| Structural highlights
Function
CSF3_HUMAN Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.,Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K. Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme. Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111 doi:10.1038/44394
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