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1pjc

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L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD

Structural highlights

1pjc is a 1 chain structure with sequence from Phormidium lapideum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O52942_PHOLP

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.

Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.,Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW. Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase. Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169 doi:http://dx.doi.org/10.1038/817

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1pjc"

@@ Line 3: / Line 3: @@
 <StructureSection load='1pjc' size='340' side='right'caption='[[1pjc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1pjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pholp Pholp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PJC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1pjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjc OCA], [http://pdbe.org/1pjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pjc RCSB], [http://www.ebi.ac.uk/pdbsum/1pjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjc ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjc OCA], [https://pdbe.org/1pjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjc RCSB], [https://www.ebi.ac.uk/pdbsum/1pjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjc ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O52942_PHOLP O52942_PHOLP]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 31: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Alanine dehydrogenase]]
 [[Category: Large Structures]]
-[[Category: Pholp]]
+[[Category: Phormidium lapideum]]
-[[Category: Baker, P J]]
+[[Category: Baker PJ]]
-[[Category: Rice, D W]]
+[[Category: Rice DW]]
-[[Category: Sawa, Y]]
+[[Category: Sawa Y]]
-[[Category: Sedelnikova, S E]]
+[[Category: Sedelnikova SE]]
-[[Category: Shibata, H]]
+[[Category: Shibata H]]
-[[Category: Nad]]
-[[Category: Oxidoreductase]]

1pjc

From Proteopedia

Current revision

L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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