5he3

<table><tr><td colspan='2'>[[5he3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HE3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FF1:(4~{S})-4-[3-[2-(2,6-DIMETHYLPHENYL)ETHYLCARBAMOYL]-4-FLUORANYL-PHENYL]-~{N}-(1~{H}-INDAZOL-5-YL)-6-METHYL-2-OXIDANYLIDENE-3,4-DIHYDRO-1~{H}-PYRIMIDINE-5-CARBOXAMIDE'>FF1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Beta-adrenergic-receptor]_kinase [Beta-adrenergic-receptor] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.15 2.7.11.15] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5he3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he3 OCA], [http://pdbe.org/5he3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5he3 RCSB], [http://www.ebi.ac.uk/pdbsum/5he3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5he3 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/ARBK1_BOVIN ARBK1_BOVIN]] Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref>

 

 

*[[Transducin|Transducin]]

[[Category: Bovin]]

[[Category: Human]]

[[Category: Cato, M C]]

[[Category: Tesmer, J J.G]]

[[Category: Wd-40]]