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5l2m

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Current revision (16:05, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5l2m' size='340' side='right'caption='[[5l2m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='5l2m' size='340' side='right'caption='[[5l2m]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l2m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L2M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L2M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZY:2,3,5-TRIMETHYL-6-[3-OXO-3-(PIPERIDIN-1-YL)PROPYL]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE'>6ZY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6ZY:2,3,5-TRIMETHYL-6-[3-OXO-3-(PIPERIDIN-1-YL)PROPYL]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE'>6ZY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l13|5l13]], [[5l2n|5l2n]], [[5l2o|5l2o]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2m OCA], [https://pdbe.org/5l2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l2m RCSB], [https://www.ebi.ac.uk/pdbsum/5l2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2m ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ALDH1A1, ALDC, ALDH1, PUMB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l2m OCA], [http://pdbe.org/5l2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l2m RCSB], [http://www.ebi.ac.uk/pdbsum/5l2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l2m ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
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[https://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Buchman, C D]]
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[[Category: Buchman CD]]
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[[Category: Hurley, T D]]
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[[Category: Hurley TD]]
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[[Category: Aldh1a1 inhibitor]]
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[[Category: Oxidoreductase-oxidoreductase inihbitor complex]]
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Current revision

Structure of ALDH1A1 in complex with BUC11

PDB ID 5l2m

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