1r2x

<StructureSection load='1r2x' size='340' side='right'caption='[[1r2x]], [[Resolution|resolution]] 9.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[1r2x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R2X FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ffk|1ffk]], [[1qza|1qza]], [[1qzb|1qzb]], [[1qzc|1qzc]], [[1qzd|1qzd]], [[1r2w|1r2w]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2x OCA], [http://pdbe.org/1r2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r2x RCSB], [http://www.ebi.ac.uk/pdbsum/1r2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2x ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RL11_THEMA RL11_THEMA]] This protein binds directly to 23S ribosomal RNA.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Aminoacyl-tRNAs (aa-tRNAs) are delivered to the ribosome as part of the ternary complex of aa-tRNA, elongation factor Tu (EF-Tu) and GTP. Here, we present a cryo-electron microscopy (cryo-EM) study, at a resolution of approximately 9 A, showing that during the incorporation of the aa-tRNA into the 70S ribosome of Escherichia coli, the flexibility of aa-tRNA allows the initial codon recognition and its accommodation into the ribosomal A site. In addition, a conformational change observed in the GTPase-associated center (GAC) of the ribosomal 50S subunit may provide the mechanism by which the ribosome promotes a relative movement of the aa-tRNA with respect to EF-Tu. This relative rearrangement seems to facilitate codon recognition by the incoming aa-tRNA, and to provide the codon-anticodon recognition-dependent signal for the GTPase activity of EF-Tu. From these new findings we propose a mechanism that can explain the sequence of events during the decoding of mRNA on the ribosome.

Incorporation of aminoacyl-tRNA into the ribosome as seen by cryo-electron microscopy.,Valle M, Zavialov A, Li W, Stagg SM, Sengupta J, Nielsen RC, Nissen P, Harvey SC, Ehrenberg M, Frank J Nat Struct Biol. 2003 Nov;10(11):899-906. Epub 2003 Oct 19. PMID:14566331<ref>PMID:14566331</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1r2x" style="background-color:#fffaf0;"></div>

*[[Ribosomal protein L11|Ribosomal protein L11]]

</StructureSection>

[[Category: Ehrenberg, M]]

[[Category: Frank, J]]

[[Category: Harvey, S C]]

[[Category: Li, W]]

[[Category: Nielsen, R C]]

[[Category: Nissen, P]]

[[Category: Sengupta, J]]

[[Category: Stagg, S M]]

[[Category: Valle, M]]

[[Category: Zavialov, A]]

[[Category: Rna binding protein-rna complex]]