1r5z
From Proteopedia
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<StructureSection load='1r5z' size='340' side='right'caption='[[1r5z]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='1r5z' size='340' side='right'caption='[[1r5z]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1r5z]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1r5z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R5Z FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r5z OCA], [https://pdbe.org/1r5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r5z RCSB], [https://www.ebi.ac.uk/pdbsum/1r5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r5z ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/VATC_THET8 VATC_THET8] Produces ATP from ADP in the presence of a proton gradient across the membrane. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5z ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r5z ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
- | <div style="background-color:#fffaf0;"> | ||
- | == Publication Abstract from PubMed == | ||
- | The vacuole-type ATPases (V-ATPases) exist in various intracellular compartments of eukaryotic cells to regulate physiological processes by controlling the acidic environment. The crystal structure of the subunit C of Thermus thermophilus V-ATPase, homologous to eukaryotic subunit d of V-ATPases, has been determined at 1.95-A resolution and located into the holoenzyme complex structure obtained by single particle analysis as suggested by the results of subunit cross-linking experiments. The result shows that V-ATPase is substantially longer than the related F-type ATPase, due to the insertion of subunit C between the V(1) (soluble) and the V(o) (membrane bound) domains. Subunit C, attached to the V(o) domain, seems to have a socket like function in attaching the central-stalk subunits of the V(1) domain. This architecture seems essential for the reversible association/dissociation of the V(1) and the V(o) domains, unique for V-ATPase activity regulation. | ||
- | |||
- | Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase.,Iwata M, Imamura H, Stambouli E, Ikeda C, Tamakoshi M, Nagata K, Makyio H, Hankamer B, Barber J, Yoshida M, Yokoyama K, Iwata S Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):59-64. Epub 2003 Dec 18. PMID:14684831<ref>PMID:14684831</ref> | ||
- | |||
- | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
- | </div> | ||
- | <div class="pdbe-citations 1r5z" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[ATPase 3D structures|ATPase 3D structures]] | *[[ATPase 3D structures|ATPase 3D structures]] | ||
- | == References == | ||
- | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: Flavobacterium thermophilum yoshida and oshima 1971]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Barber | + | [[Category: Thermus thermophilus]] |
- | [[Category: Hankamer | + | [[Category: Barber J]] |
- | [[Category: Ikeda | + | [[Category: Hankamer B]] |
- | [[Category: Imamura | + | [[Category: Ikeda C]] |
- | [[Category: Iwata | + | [[Category: Imamura H]] |
- | [[Category: Iwata | + | [[Category: Iwata M]] |
- | [[Category: Makyio | + | [[Category: Iwata S]] |
- | [[Category: Nagata | + | [[Category: Makyio H]] |
- | [[Category: Stambouli | + | [[Category: Nagata K]] |
- | [[Category: Tamakoshi | + | [[Category: Stambouli E]] |
- | [[Category: Yokoyama | + | [[Category: Tamakoshi M]] |
- | [[Category: Yoshida | + | [[Category: Yokoyama K]] |
- | + | [[Category: Yoshida M]] | |
- | + |
Current revision
Crystal Structure of Subunit C of V-ATPase
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Categories: Large Structures | Thermus thermophilus | Barber J | Hankamer B | Ikeda C | Imamura H | Iwata M | Iwata S | Makyio H | Nagata K | Stambouli E | Tamakoshi M | Yokoyama K | Yoshida M