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Rac
From Proteopedia
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== Function == | == Function == | ||
| - | The small G-protein '''Rac''' or '''Ras-related C3 botulinum toxin substrate'''. ''' | + | The small G-protein '''Rac''' or '''Ras-related C3 botulinum toxin substrate'''. |
| + | *'''Rac1''' is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes<ref>PMID:23412604</ref>. | ||
| + | *'''Rac2''' is expressed in hematopoietic cells exclusively<ref>PMID:32542921</ref>. | ||
| + | * '''Rac3''' binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. | ||
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of Rac== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *Rac1 | ||
| - | |||
| - | **[[3th5]], [[1ryh]], [[1mh1]] – hRac1 + GNP – human<br /> | ||
| - | **[[2p2l]], [[1ryf]], [[5n6o]] – hRac1 + GDP <br /> | ||
| - | **[[6agp]] – hRac1 (mutant) + GDP <br /> | ||
| - | **[[4gzl]], [[3sbd]], [[3sbe]] – hRac1 (mutant) + GNP <br /> | ||
| - | **[[4gzm]] – hRac1 (mutant) + GSP <br /> | ||
| - | **[[5hzh]], [[2wkp]], [[2wkq]], [[2wkr]] – hRac1 LOV2 domain (mutant) + GTP + MFN <br /> | ||
| - | **[[5vcu]] - Rac1 + GDP - ''Naegleria fowleri''<br /> | ||
| - | |||
| - | *Rac1 complex with protein | ||
| - | |||
| - | **[[5fi0]] – hRac1 + PTDINS (3,4,5)-dependent Rac exchanger <br /> | ||
| - | **[[4yon]] – hRac1 (mutant) + PTDINS (3,4,5)-dependent Rac exchanger <br /> | ||
| - | **[[2yin]] – hRac1 + dedicator of cytokinesis protein 2 <br /> | ||
| - | **[[3b13]] – hRac1 (mutant) + dedicator of cytokinesis protein 2 <br /> | ||
| - | **[[3bji]], [[2vrw]] – hRac1 + proto-oncogene VAV <br /> | ||
| - | **[[2nz8]] – hRac1 + triple functional domain protein<br /> | ||
| - | **[[1foe]] – hRac1 + TIAM1 <br /> | ||
| - | **[[2nz8]] - hRac1 + TRIO N-terminal<br /> | ||
| - | |||
| - | *Rac1 complex with protein and nucleotide | ||
| - | |||
| - | **[[3ryt]] – hRac1 (mutant) + plexin-A1 + GNP<br /> | ||
| - | **[[3su8]], [[3sua]] – hRac1 (mutant) + plexin-B1 + GNP<br /> | ||
| - | **[[2rmk]] – hRac1 (mutant) + PRK1 + GCP - NMR<br /> | ||
| - | **[[2fju]] – hRac1 + phospholipase C beta 2 + GSP <br /> | ||
| - | **[[2h7v]] – hRac1 (mutant) + YpkA + GDP <br /> | ||
| - | **[[1hh4]], [[1ds6]] – hRac1 + RhoGD1 + GDP <br /> | ||
| - | **[[6bc1]] – hRac1 + RhoGEF + GTP analog<br /> | ||
| - | **[[1i4d]], [[1i4l]] – hRac1 + arfaptin + GDP <br /> | ||
| - | **[[1i4t]] – hRac1 + arfaptin + GNP <br /> | ||
| - | **[[1g4u]] – hRac1 (mutant) + SPTP + GDP <br /> | ||
| - | **[[1he1]] – hRac1 + GTPase-activating protein + GDP <br /> | ||
| - | **[[1e96]] – hRac1 (mutant) + neutrophil cytosol factor 2 + GTP <br /> | ||
| - | **[[5o33]] - hRac1 + kalirin + GDP<br /> | ||
| - | |||
| - | *Rac2 | ||
| - | |||
| - | **[[2w2t]] – hRac2 (mutant) + GDP <br /> | ||
| - | **[[2w2v]] – hRac2 (mutant) + GDTP <br /> | ||
| - | **[[2w2x]] – hRac2 (mutant) + PLCG2 + GSP <br /> | ||
| - | |||
| - | *Rac3 | ||
| - | **[[2qme]] – hRac3 + PAK1 + GCP <br /> | ||
| - | **[[2ov2]] – hRac3 + PAK4 + GCP <br /> | ||
| - | **[[2ic5]] – hRac3 + GDP + GNP <br /> | ||
| - | **[[2g0n]], [[2c2h]] – hRac3 + GDP <br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013, Feb 15. PMID:23412604 doi:http://dx.doi.org/10.1007/s00125-013-2849-5
- ↑ Lougaris V, Baronio M, Gazzurelli L, Benvenuto A, Plebani A. RAC2 and primary human immune deficiencies. J Leukoc Biol. 2020 Aug;108(2):687-696. PMID:32542921 doi:10.1002/JLB.5MR0520-194RR
- ↑ Prehna G, Ivanov MI, Bliska JB, Stebbins CE. Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors. Cell. 2006 Sep 8;126(5):869-80. PMID:16959567 doi:10.1016/j.cell.2006.06.056
