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6lgw
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH== | |
| + | <StructureSection load='6lgw' size='340' side='right'caption='[[6lgw]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6lgw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rabies_lyssavirus Rabies lyssavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LGW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LGW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9037Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lgw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lgw OCA], [https://pdbe.org/6lgw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lgw RCSB], [https://www.ebi.ac.uk/pdbsum/6lgw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lgw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLYCO_RABVC GLYCO_RABVC] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Antibody 3D structures|Antibody 3D structures]] | |
| - | + | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Rabies lyssavirus]] | ||
| + | [[Category: Cao Y]] | ||
| + | [[Category: Chen H]] | ||
| + | [[Category: Chen ZJ]] | ||
| + | [[Category: Chen ZM]] | ||
| + | [[Category: Cheng YW]] | ||
| + | [[Category: Gao GF]] | ||
| + | [[Category: Li YH]] | ||
| + | [[Category: Lin S]] | ||
| + | [[Category: Lin X]] | ||
| + | [[Category: Lu GW]] | ||
| + | [[Category: Qi JX]] | ||
| + | [[Category: Sun HL]] | ||
| + | [[Category: Wang JC]] | ||
| + | [[Category: Wei YQ]] | ||
| + | [[Category: Yang FL]] | ||
| + | [[Category: Yang J]] | ||
| + | [[Category: Yang M]] | ||
| + | [[Category: Yang SY]] | ||
| + | [[Category: Yang Y]] | ||
| + | [[Category: Ye F]] | ||
| + | [[Category: You Y]] | ||
| + | [[Category: Yue D]] | ||
| + | [[Category: Zhang ZL]] | ||
Current revision
Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH
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