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6v5c

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'''Unreleased structure'''
 
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The entry 6v5c is ON HOLD
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==Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state==
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<StructureSection load='6v5c' size='340' side='right'caption='[[6v5c]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6v5c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6V5C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6v5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v5c OCA], [https://pdbe.org/6v5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6v5c RCSB], [https://www.ebi.ac.uk/pdbsum/6v5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6v5c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNC_HUMAN RNC_HUMAN] Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.<ref>PMID:10948199</ref> <ref>PMID:14508493</ref> <ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:15565168</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:17159994</ref>
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Authors:
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chiu W]]
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[[Category: Herrell E]]
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[[Category: Jeong B]]
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[[Category: Li S]]
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[[Category: Nam Y]]
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[[Category: Partin A]]
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[[Category: Zhang K]]

Current revision

Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state

PDB ID 6v5c

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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