1py9

From Proteopedia

(Difference between revisions)

Current revision

The crystal structure of an autoantigen in multiple sclerosis

Structural highlights

1py9 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MOG_MOUSE Note=Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.

Function

MOG_MOUSE Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. To gain new insights into the physiological and immunopathological role of MOG, we determined the 1.8-A crystal structure of the MOG extracellular domain (MOGED). MOGED adopts a classical Ig (Ig variable domain) fold that was observed to form an antiparallel head-to-tail dimer. A dimeric form of native MOG was observed, and MOGED was also shown to dimerize in solution, consistent with the view of MOG acting as a homophilic adhesion receptor. The MOG35-55 peptide, a major encephalitogenic determinant recognized by both T cells and demyelinating autoantibodies, is partly occluded within the dimer interface. The structure of this key autoantigen suggests a relationship between the dimeric form of MOG within the myelin sheath and a breakdown of immunological tolerance to MOG that is observed in multiple sclerosis.

The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis.,Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5. PMID:12960396^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5. PMID:12960396 doi:http://dx.doi.org/10.1073/pnas.1833158100
↑ Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11059-64. Epub 2003 Sep 5. PMID:12960396 doi:http://dx.doi.org/10.1073/pnas.1833158100

1 Structural highlights
2 Disease
3 Function
4 Evolutionary Conservation
5 Publication Abstract from PubMed
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1py9"

@@ Line 3: / Line 3: @@
 <StructureSection load='1py9' size='340' side='right'caption='[[1py9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1py9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PY9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1py9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PY9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MOG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1py9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1py9 OCA], [http://pdbe.org/1py9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1py9 RCSB], [http://www.ebi.ac.uk/pdbsum/1py9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1py9 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1py9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1py9 OCA], [https://pdbe.org/1py9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1py9 RCSB], [https://www.ebi.ac.uk/pdbsum/1py9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1py9 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE]] Note=Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.
+[https://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE] Note=Reduced concentrations of Mog are observed in jimpy and quacking dysmyelinating mutant mice.
 == Function ==
-[[http://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE]] Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.<ref>PMID:12960396</ref>
+[https://www.uniprot.org/uniprot/MOG_MOUSE MOG_MOUSE] Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion.<ref>PMID:12960396</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 17: / Line 17: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/py/1py9_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 36: / Line 36: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Beddoe, T]]
+[[Category: Beddoe T]]
-[[Category: Bernard, C C]]
+[[Category: Bernard CC]]
-[[Category: Clements, C S]]
+[[Category: Clements CS]]
-[[Category: Johns, T G]]
+[[Category: Johns TG]]
-[[Category: Perugini, M A]]
+[[Category: Perugini MA]]
-[[Category: Reid, H H]]
+[[Category: Reid HH]]
-[[Category: Rossjohn, J]]
+[[Category: Rossjohn J]]
-[[Category: Tynan, F E]]
+[[Category: Tynan FE]]
-[[Category: Anti-parallel dimer]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin]]
-[[Category: Multiple sclerosis]]
-[[Category: Myelin sheath]]
-[[Category: Receptor]]

1py9

From Proteopedia

Current revision

The crystal structure of an autoantigen in multiple sclerosis

Structural highlights

Disease

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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