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| | <StructureSection load='4z24' size='340' side='right'caption='[[4z24]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='4z24' size='340' side='right'caption='[[4z24]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4z24]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Apmv Apmv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z24 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z24 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4z24]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_polyphaga_mimivirus Acanthamoeba polyphaga mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z24 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z25|4z25]], [[4z26|4z26]]</td></tr>
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIMI_R135 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=212035 APMV])</td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z24 OCA], [https://pdbe.org/4z24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z24 RCSB], [https://www.ebi.ac.uk/pdbsum/4z24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z24 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z24 OCA], [http://pdbe.org/4z24 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z24 RCSB], [http://www.ebi.ac.uk/pdbsum/4z24 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z24 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/YR135_MIMIV YR135_MIMIV] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Apmv]] | + | [[Category: Acanthamoeba polyphaga mimivirus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Klose, T]] | + | [[Category: Klose T]] |
| - | [[Category: Rossmann, M G]] | + | [[Category: Rossmann MG]] |
| - | [[Category: Fad]]
| + | |
| - | [[Category: Fiber]]
| + | |
| - | [[Category: Gmc oxidoreductase]]
| + | |
| - | [[Category: Oxidoreductase]]
| + | |
| Structural highlights
Function
YR135_MIMIV
Publication Abstract from PubMed
Mimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba. The structure of R135, a major component of the fibrous outer layer of Mimivirus, has been determined to 2-A resolution. The protein's structure is similar to that of members of the glucose-methanol-choline oxidoreductase family, which have an N-terminal FAD binding domain and a C-terminal substrate recognition domain. The closest homolog to R135 is an aryl-alcohol oxidase that participates in lignin biodegradation of plant cell walls. Thus R135 might participate in the degradation of their normal hosts, including some lignin-containing algae.
A Mimivirus Enzyme that Participates in Viral Entry.,Klose T, Herbst DA, Zhu H, Max JP, Kenttamaa HI, Rossmann MG Structure. 2015 Jun 2;23(6):1058-65. doi: 10.1016/j.str.2015.03.023. Epub 2015, May 14. PMID:25982526[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Klose T, Herbst DA, Zhu H, Max JP, Kenttamaa HI, Rossmann MG. A Mimivirus Enzyme that Participates in Viral Entry. Structure. 2015 Jun 2;23(6):1058-65. doi: 10.1016/j.str.2015.03.023. Epub 2015, May 14. PMID:25982526 doi:http://dx.doi.org/10.1016/j.str.2015.03.023
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