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5vx8

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Current revision (14:01, 4 October 2023) (edit) (undo)
 
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<StructureSection load='5vx8' size='340' side='right'caption='[[5vx8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5vx8' size='340' side='right'caption='[[5vx8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5vx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_group_a_rotavirus Human group a rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5vx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_rotavirus_A Human rotavirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VX8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx8 OCA], [http://pdbe.org/5vx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx8 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx8 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx8 OCA], [https://pdbe.org/5vx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vx8 RCSB], [https://www.ebi.ac.uk/pdbsum/5vx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/D7F7M7_9REOV D7F7M7_9REOV]] Outer capsid protein VP5*: Forms the spike "foot" and "body" and acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. During entry, the part of VP5* that protrudes from the virus folds back on itself and reorganizes from a local dimer to a trimer. This reorganization may be linked to membrane penetration by exposing VP5* hydrophobic region. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS01043052]
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[https://www.uniprot.org/uniprot/D7F7M7_9VIRU D7F7M7_9VIRU]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5vx8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5vx8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human group a rotavirus]]
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[[Category: Human rotavirus A]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hu, L]]
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[[Category: Hu L]]
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[[Category: Prasad, B V.Venkataram]]
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[[Category: Venkataram Prasad BV]]
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[[Category: Glycan]]
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[[Category: Hbga]]
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[[Category: Rotavirus]]
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[[Category: Viral protein]]
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Current revision

VP8* of P[6] Human Rotavirus RV3

PDB ID 5vx8

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OCA

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