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6kry

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==Sructure of staphylococcal enterotoxin SEN==
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==Structure of staphylococcal enterotoxin SEN==
<StructureSection load='6kry' size='340' side='right'caption='[[6kry]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='6kry' size='340' side='right'caption='[[6kry]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6kry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6kry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KRY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sen, ERS072840_00070, NCTC7878_02454 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kry OCA], [http://pdbe.org/6kry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kry RCSB], [http://www.ebi.ac.uk/pdbsum/6kry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kry ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kry OCA], [https://pdbe.org/6kry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kry RCSB], [https://www.ebi.ac.uk/pdbsum/6kry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kry ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6YCN3_STAAU Q6YCN3_STAAU]
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Staphylococcus aureus strains produce a unique family of immunostimulatory exotoxins termed as bacterial superantigens (SAgs), which cross-link major histocompatibility complex class II (MHC II) molecule and T-cell receptor (TCR) to stimulate large numbers of T cells at extremely low concentrations. SAgs are associated with food poisoning and toxic shock syndrome. To date, 26 genetically distinct staphylococcal SAgs have been reported. This study reports the first X-ray structure of newly characterized staphylococcal enterotoxin N (SEN). SEN possesses the classical two domain architecture that includes an N-terminal oligonucleotide-binding fold and a C-terminal beta-grasp domain. Amino acid and structure alignments revealed that several critical amino acids that are proposed to be responsible for MHC II and TCR molecule engagements are variable in SEN, suggesting that SEN may adopt a different binding mode to its cellular receptors. This work helps better understand the mechanisms of action of SAgs.
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Structure of Staphylococcal Enterotoxin N: Implications for Binding Properties to Its Cellular Proteins.,Zeng C, Liu Z, Han Z Int J Mol Sci. 2019 Nov 25;20(23). pii: ijms20235921. doi: 10.3390/ijms20235921. PMID:31775346<ref>PMID:31775346</ref>
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==See Also==
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*[[Exotoxin 3D structures|Exotoxin 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6kry" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Han, Z]]
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[[Category: Staphylococcus aureus]]
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[[Category: Zeng, C]]
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[[Category: Han Z]]
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[[Category: Allergen]]
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[[Category: Zeng C]]
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[[Category: Sen]]
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[[Category: Staphylococcal enterotoxin]]
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Current revision

Structure of staphylococcal enterotoxin SEN

PDB ID 6kry

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