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| | <StructureSection load='2ce4' size='340' side='right'caption='[[2ce4]], [[Resolution|resolution]] 2.20Å' scene=''> | | <StructureSection load='2ce4' size='340' side='right'caption='[[2ce4]], [[Resolution|resolution]] 2.20Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2ce4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deira Deira]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CE4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2ce4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CE4 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y67|1y67]], [[2cdy|2cdy]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ce4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ce4 OCA], [https://pdbe.org/2ce4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ce4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ce4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ce4 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ce4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ce4 OCA], [http://pdbe.org/2ce4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ce4 RCSB], [http://www.ebi.ac.uk/pdbsum/2ce4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ce4 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/SODM_DEIRA SODM_DEIRA] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | ==See Also== | | ==See Also== |
| - | *[[Superoxide Dismutase|Superoxide Dismutase]] | + | *[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Deira]] | + | [[Category: Deinococcus radiodurans R1]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Superoxide dismutase]]
| + | [[Category: Dennis R]] |
| - | [[Category: Dennis, R]] | + | [[Category: Gordon E]] |
| - | [[Category: Gordon, E]] | + | [[Category: Leonard G]] |
| - | [[Category: Leonard, G]] | + | [[Category: McCarthy J]] |
| - | [[Category: McCarthy, J]] | + | [[Category: McSweeney S]] |
| - | [[Category: McSweeney, S]] | + | [[Category: Micossi E]] |
| - | [[Category: Micossi, E]] | + | [[Category: Moe E]] |
| - | [[Category: Moe, E]] | + | |
| - | [[Category: Deinococcus radioduran]]
| + | |
| - | [[Category: Manganese superoxide dismutase]]
| + | |
| - | [[Category: Oxidoreductase]]
| + | |
| - | [[Category: Radiation resistance]]
| + | |
| Structural highlights
Function
SODM_DEIRA Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from Deinococcus radiodurans has been determined in two different crystal forms. Both crystal forms are monoclinic with space group P2(1). Form I has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta = 110.18 degrees and contains a homodimer in the asymmetric unit, with structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.57, b = 87.10, c = 116.42 angstroms, beta = 92.1 degrees and an asymmetric unit containing two Mn-SOD homodimers; structure refinement was effected to a resolution of 2.0 angstroms (R = 17.2%, R(free) = 22.3%). The resulting structures are compared with that of Mn-SOD from Escherichia coli, with which they are shown to be essentially isostructural.
Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.,Dennis RJ, Micossi E, McCarthy J, Moe E, Gordon EJ, Kozielski-Stuhrmann S, Leonard GA, McSweeney S Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):325-9. Epub 2006 Mar 25. PMID:16582477[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Dennis RJ, Micossi E, McCarthy J, Moe E, Gordon EJ, Kozielski-Stuhrmann S, Leonard GA, McSweeney S. Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):325-9. Epub 2006 Mar 25. PMID:16582477 doi:10.1107/S1744309106008402
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