2cls
From Proteopedia
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<StructureSection load='2cls' size='340' side='right'caption='[[2cls]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='2cls' size='340' side='right'caption='[[2cls]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cls]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cls]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.31Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cls OCA], [https://pdbe.org/2cls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cls RCSB], [https://www.ebi.ac.uk/pdbsum/2cls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cls ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | ||
| + | *[[Rho GTPase 3D structures|Rho GTPase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bray | + | [[Category: Bray J]] |
| - | [[Category: Colebrook | + | [[Category: Colebrook S]] |
| - | [[Category: Debreczeni | + | [[Category: Debreczeni JE]] |
| - | + | [[Category: Doyle D]] | |
| - | [[Category: Doyle | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Elkins J]] |
| - | [[Category: Elkins | + | [[Category: Gileadi O]] |
| - | [[Category: Gileadi | + | [[Category: Marsden B]] |
| - | + | [[Category: Pike ACW]] | |
| - | [[Category: Marsden | + | [[Category: Schoch G]] |
| - | [[Category: Pike | + | [[Category: Sobott F]] |
| - | [[Category: Schoch | + | [[Category: Sundstrom M]] |
| - | [[Category: Sobott | + | [[Category: Turnbull AP]] |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Turnbull | + | [[Category: Wen Hwa L]] |
| - | [[Category: Weigelt | + | [[Category: Yang X]] |
| - | [[Category: | + | [[Category: Zhao Y]] |
| - | [[Category: | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
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Current revision
The crystal structure of the human RND1 GTPase in the active GTP bound state
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bray J | Colebrook S | Debreczeni JE | Doyle D | Edwards A | Elkins J | Gileadi O | Marsden B | Pike ACW | Schoch G | Sobott F | Sundstrom M | Turnbull AP | Weigelt J | Wen Hwa L | Yang X | Zhao Y | Von Delft F
