2btq

From Proteopedia

(Difference between revisions)

Current revision

Structure of BtubAB heterodimer from Prosthecobacter dejongeii

Structural highlights

2btq is a 2 chain structure with sequence from Prosthecobacter dejongeii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.2Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8GCC5_9BACT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

alphabeta-Tubulin heterodimers, from which the microtubules of the cytoskeleton are built, have a complex chaperone-dependent folding pathway. They are thought to be unique to eukaryotes, whereas the homologue FtsZ can be found in bacteria. The exceptions are BtubA and BtubB from Prosthecobacter, which have higher sequence homology to eukaryotic tubulin than to FtsZ. Here we show that some of their properties are different from tubulin, such as weak dimerization and chaperone-independent folding. However, their structure is strikingly similar to tubulin including surface loops, and BtubA/B form tubulin-like protofilaments. Presumably, BtubA/B were transferred from a eukaryotic cell by horizontal gene transfer because their high degree of similarity to eukaryotic genes is unique within the Prosthecobacter genome.

Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer.,Schlieper D, Oliva MA, Andreu JM, Lowe J Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9170-5. Epub 2005 Jun 20. PMID:15967998^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Schlieper D, Oliva MA, Andreu JM, Lowe J. Structure of bacterial tubulin BtubA/B: evidence for horizontal gene transfer. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9170-5. Epub 2005 Jun 20. PMID:15967998

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2btq"

Categories: Large Structures | Prosthecobacter dejongeii | Lowe J | Schlieper D

@@ Line 3: / Line 3: @@
 <StructureSection load='2btq' size='340' side='right'caption='[[2btq]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2btq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27091 Atcc 27091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2btq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Prosthecobacter_dejongeii Prosthecobacter dejongeii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bto|2bto]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2btq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2btq OCA], [http://pdbe.org/2btq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2btq RCSB], [http://www.ebi.ac.uk/pdbsum/2btq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2btq ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2btq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2btq OCA], [https://pdbe.org/2btq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2btq RCSB], [https://www.ebi.ac.uk/pdbsum/2btq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2btq ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8GCC5_9BACT Q8GCC5_9BACT]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 30: / Line 32: @@
 ==See Also==
 *[[BtuB 3D structures|BtuB 3D structures]]
-*[[Tubulin|Tubulin]]
+*[[Tubulin 3D Structures|Tubulin 3D Structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Atcc 27091]]
 [[Category: Large Structures]]
-[[Category: Lowe, J]]
+[[Category: Prosthecobacter dejongeii]]
-[[Category: Schlieper, D]]
+[[Category: Lowe J]]
-[[Category: Bacterial tubulin]]
+[[Category: Schlieper D]]
-[[Category: Cytoskeletal protein]]
-[[Category: Cytoskeletal protein-complex]]
-[[Category: Cytoskeleton]]
-[[Category: Polymerization]]
-[[Category: Protein complex]]
-[[Category: Structural protein]]
-[[Category: Verrucomicrobia]]

2btq

From Proteopedia

Current revision

Structure of BtubAB heterodimer from Prosthecobacter dejongeii

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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