Ribonuclease

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<StructureSection load="1rta" size="350" color="" spin="on" Scene= caption='Ribonuclease A (magenta) complex with thymidylic acid DNA tetramer (pink), [[1rta]]' >
<StructureSection load="1rta" size="350" color="" spin="on" Scene= caption='Ribonuclease A (magenta) complex with thymidylic acid DNA tetramer (pink), [[1rta]]' >
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== Function ==
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== Function ==
'''Ribonuclease''' (RNase) degrades RNA. The '''endonucleases''' cleave single or double stranded RNA. '''Exo-RNases''' remove terminal nucleotide from the ends of the RNA molecule. <br />
'''Ribonuclease''' (RNase) degrades RNA. The '''endonucleases''' cleave single or double stranded RNA. '''Exo-RNases''' remove terminal nucleotide from the ends of the RNA molecule. <br />
* '''RNase A''' or '''RNase I''' endonuclease which cleaves C or U of single-stranded RNA (ssRNA)<ref>PMID:15676279</ref>. For details see [[RNase A]], [[RNase A Oligomers]], [[Ribonuclease A Catalysis]], [[RNaseA Nobel Prizes]], [[User:R. Jeremy Johnson/RNaseA]] and [[RNase A NMR]].<br />
* '''RNase A''' or '''RNase I''' endonuclease which cleaves C or U of single-stranded RNA (ssRNA)<ref>PMID:15676279</ref>. For details see [[RNase A]], [[RNase A Oligomers]], [[Ribonuclease A Catalysis]], [[RNaseA Nobel Prizes]], [[User:R. Jeremy Johnson/RNaseA]] and [[RNase A NMR]].<br />
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* '''RNase L''' activates the inflammasome during viral infection<ref>PMID:25816776</ref>.<br />
* '''RNase L''' activates the inflammasome during viral infection<ref>PMID:25816776</ref>.<br />
* '''RNase MC1''' from bitter gourd has a preference for cleavage at the 5'-end of uridine<ref>PMID:10964705</ref>.<br />
* '''RNase MC1''' from bitter gourd has a preference for cleavage at the 5'-end of uridine<ref>PMID:10964705</ref>.<br />
 +
* '''RNase MRP''' processes RNA from the mitochondrial displacement loop-containing region<ref>PMID:7688115</ref>.<br />
* ''' RNase P''' is an endonuclease which is a ribozyme<ref>PMID:14580343</ref>. For details see [[RNase P]], [[RNase P Nobel Prizes]].<br />
* ''' RNase P''' is an endonuclease which is a ribozyme<ref>PMID:14580343</ref>. For details see [[RNase P]], [[RNase P Nobel Prizes]].<br />
* '''RNase PH''' is an exonuclease involved in the trimming of the 3' terminus of tRNA<ref>PMID:2455297</ref>.<br />
* '''RNase PH''' is an exonuclease involved in the trimming of the 3' terminus of tRNA<ref>PMID:2455297</ref>.<br />
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* '''Binase''' is a microbial RNase which cleaves endonucleolyticly ssRNA<ref>PMID:25551440</ref>.<br />
* '''Binase''' is a microbial RNase which cleaves endonucleolyticly ssRNA<ref>PMID:25551440</ref>.<br />
* '''Poly(A)-specific RNase''' cleaves exonucleolyticly the poly(A) tail<ref>PMID:23912222</ref>.<br />
* '''Poly(A)-specific RNase''' cleaves exonucleolyticly the poly(A) tail<ref>PMID:23912222</ref>.<br />
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For more details on RNase A see:<br />
+
* '''NanoRNase''' cleaves RNA fragments of 2-5 nucleotides which are generated by RNA degradation<ref>PMID:28894100</ref>.<br />
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<br />
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* '''MiniRNase''' RNase with the catalytic domain but lacking the specificity domain<ref>PMID:21135215</ref>.<br />
== Relevance ==
== Relevance ==
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</StructureSection>
</StructureSection>
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== 3D Structures of Ribonuclease ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*RNase I or RNase A
 
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**[[4kxh]] - hRNase I - human<br />
 
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**[[3f8g]], [[2e0j]], [[2e0l]], [[2e0m]], [[2e0o]], [[1h8x]], [[1e21]], [[1dza]] - hRNase I pancreatic (mutant) <br />
 
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**[[2k11]] - hRNase I pancreatic - NMR<br />
 
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**[[3mwq]], [[3mx8]], [[3i67]], [[3i6f]], [[3i6h]], [[3i6j]], [[3i7w]], [[3eux]], [[3euy]], [[3euz]], [[3ev0]], [[3ev1]], [[3ev2]], [[3ev3]], [[3ev4]], [[3ev5]], [[3ev6]], [[3dh5]], [[2e3w]], [[2g4w]], [[2g4x]], [[2gbq]], [[2blp]], [[2blz]], [[2jvt]], [[1jvv]], [[1jvt]], [1js0]], [[1fs3]], [[1kf2]], [[1kf3]], [[1kf4]], [[1kf5]], [[1kf7]], [[1kf8]], [[1aqp]], [[1a2w]], [[1rnw]], [[1rnz]], [[1rno]], [[1rnq]], [[1rbx]], [[1ssc]], [[3srn]], [[4srn]], [[1srn]], [[5rsa]], [[1afu]], [[1bel]], [[1c0b]], [[1c0c]], [[1lsq]], [[1rat]], [[1rbn]], [[1rha]], [[1rhb]], [[1rnx]], [[1rny]], [[1rsm]], [[1xps]], [[1xpt]], [[2g8q]], [[2rat]], [[3mzq]], [[3mzr]], [[3rat]], [[3rn3]], [[4rat]], [[5rat]], [[6rat]], [[7rat]], [[7rsa]], [[8rat]], [[8rsa]], [[9rat]], [[9rsa]], [[3mwr]], [[4ao1]], [[4j5z]], [[4j60]], [[4j61]], [[4j62]], [[4j63]], [[4j64]], [[4j65]], [[4j66]], [[4j67]], [[4j68]], [[4j69]], [[4j6a]], [[4mxf]], [[4ooh]], [[4ot4]], [[4qh3]], [[4rte]], [[4s0q]], [[4s18]], [[5d6u]], [[5jmg]], [[5jml]], [[5na9]], [[5obc]], [[5obd]], [[5obe]], [[4srn]], [[6etr]], [[6etq]], [[6etp]], [[6eto]], [[6etn]], [[6etm]], [[6etl]], [[6etk]] - bRNase I pancreatic - bovine<br />
 
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**[[3a1r]], [[4zz4]], [[5d97]], [[5rsa]], [[6rsa]] - bRNase I pancreatic - neutron<br />
 
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**[[2aas]] - bRNase I pancreatic - NMR<br />
 
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**[[3i7x]], [[3i7y]], [[3fkz]], [[3fl3]], [[3dh6]], [[3di7]], [[3di8]], [[3di9]], [[3dib]], [[3dic]], [[2oqf]], [[3bcm]], [[3bco]], [[3bcp]], [[2nui]], [[2op2]], [[1ymn]], [[1ymr]], [[1ymw]], [[2apq]], [[1izp]], [[1izq]], [[1izr]], [[1kh8]], [[1c8w]], [[1eic]], [[1eid]], [[1eie]], [[1dy5]], [[3rsd]], [[3rsk]], [[1ssa]], [[1ssb]], [[1a5p]], [[1a5q]], [[1c9v]], [[1c9x]], [[3rsp]], [[4rsd]], [[3ql1]], [[3ql2]], [[3rh1]], [[3rid]], [[4o36]], [[4o37]], [[4k7m]], [[4k7l]], [[4okf]] - bRNase I pancreatic (mutant)<br />
 
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**[[1rar]], [[1ras]] - bRNase I pancreatic fluoroscent<br />
 
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**[[6qmn]] - RNase I pancreatic - bison<br />
 
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**[[1rra]] - RNase I - rat<br />
 
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**[[3ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I - Zebrafish<br />
 
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**[[2pqx]], [[2pqy]] - EcRNase I - ''Escherichia coli''<br />
 
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*''RNase I complex''
 
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**[[1z7x]] - hRNase I pancreatic + inhibitor<br />
 
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**[[3lxo]], [[3jw1]], [[3djo]], [[3djp]], [[3djq]], [[3djv]], [[3djx]], [[3dxg]], [[3dxh]], [[2w5g]], [[2w5i]], [[2w5k]], [[2w5l]], [[2w5m]], [[3d6o]], [[3d6p]], [[3d6q]], [[3d7b]], [[3d8y]], [[3d8z]], [[2pca]], [[2g8r]], [[1z6d]], [[1z6s]], [[1u1b]], [[1w4o]], [[1w4p]], [[1w4q]], [[1wbu]], [[1o0f]], [[1jn4]], [[1jvu]], [[1f0v]], [[1ruv]], [[1rnm]], [[1rnn]], [[1rbw]], [[1rca]], [[1rpf]], [[1rpg]], [[1rph]], [[1rnc]], [[1rnd]], [[1rob]], [[1rta]], [[1rtb]], [[1afk]], [[1afl]], [[1eos]], [[1eow]], [[1o0h]], [[1o0m]], [[1o0n]], [[1o0o]], [[1qhc]], [[1rcn]], [[2qca]], [[5ogh]] - bRNase I pancreatic + nucleotide<br />
 
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**[[6rsa]] - bRNase I pancreatic + nucleotide - neutron<br />
 
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**[[3fl0]], [[3fl1]], [[4rsk]], [[5et4]], [[4wyp]], [[4wyz]] - bRNase I pancreatic (mutant) + nucleotide <br />
 
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**[[2xog]], [[2xoi]], [[2q4g]], [[1dfj]], [[4g8v]], [[4g8y]], [[4g90]], [[5e5e]], [[5e5f]], [[5jlg]], [[6gok]], [[6f60]], [[5old]], [[5nj7]], [[6pvx]], [[6pvw]], [[6pvv]], [[6pvu]] - bRNase I pancreatic + inhibitor<br />
 
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**[[4peq]] - bRNase I pancreatic + inhibitor protein<br />
 
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**[[2p42]], [[2p43]], [[2p44]], [[2p45]], [[2p46]], [[2p47]], [[2p48]], [[2p49]], [[2p4a]], [[1bzq]], [[3qsk]], [[4pou]] - bRNase I + antibody<br />
 
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**[[2e33]] - bRNase I + F-box only protein 2<br />
 
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**[[4l55]] - bRNase I + aziru<br />
 
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**[[6qe9]] - bRNase I + Pt<br />
 
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**[[3tsr]] - mRNase I + inhibitor - mouse<br />
 
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**[[4per]] - RNase I pancreatic + inhibitor protein - chicken<br />
 
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**[[2z70]], [[2ea1]] - EcRNase I + DNA<br />
 
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*RNase II
 
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**[[2bex]] - hRNase II + RNase inhibitor protein<br />
 
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**[[2bzz]], [[2c01]], [[2c02]], [[2c05]] - hRNase II + inhibitor<br />
 
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**[[1m58]], [[1km8]], [[1km9]] - BuRNase II - Bullfrog<br />
 
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**[[1bc4]] - BuRNase II - NMR<br />
 
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**[[1m07]] - BuRNase II + DNA<br />
 
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**[[2ix0]], [[2id0]] - EcRNase II<br />
 
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**[[2ix1]] - EcRNase II (mutant)<br />
 
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*RNase III
 
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**[[1dyt]], [[1qmt]], [[2khx]] - hRNase III <br />
 
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**[[2kb5]] - hRNase III - NMR<br />
 
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**[[1h1h]] - hRNase III + nucleotide<br />
 
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**[[1z5f]] - BuRNase III<br />
 
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**[[1t4n]], [[1t4o]] - yRNase III - yeast - NMR<br />
 
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**[[2luq]] - yRNase III RNA-binding domain <br />
 
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**[[2lup]], [[4oog]], [[5t16]] - yRNase III RNA-binding domain + RNA <br />
 
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**[[2lbs]], [[1t4l]] - yRNase III RNA-binding domain + RNA - NMR<br />
 
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**[[2nue]], [[2nuf]], [[2nug]], [[1yyk]], [[1yyw]], [[4m2z]], [[4m30]] - AaRNase III + RNA - ''Aquifex aeolicus''<br />
 
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**[[2ez6]], [[1yyo]], [[1yz9]], [[1rc7]] - AaRNase III (mutant) + RNA<br />
 
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**[[1rc5]], [[1i4s]], [[1jfz]] - AaRNase III N terminal<br />
 
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**[[2a11]] - MtRNase III - ''Mycobacterium tuberculosis''<br />
 
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**[[1o0w]] - TmRNase III - ''Thermotoga maritima''<br />
 
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**[[3n3w]], [[3o2r]] - RNase III nuclease domain - ''Campylobacter jejuni''<br />
 
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*RNase III Dicer
 
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**[[4ngg]], [[4ngf]], [[4nha]] – hDicer platform-PAZ-connector helix cassette residues 765-1065 + RNA<br />
 
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**[[4ngb]], [[4ngc]], [[4ngd]], [[4ngf]], [[4ngg]], [[4nh3]], [[4nh5]], [[4nh6]], [[4nha]] – hDicer platform-PAZ-connector helix cassette (mutant) + RNA<br />
 
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**[[2eb1]] – hDicer C terminal <br />
 
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**[[4wyq]] – hDicer residues 267-389 + polypeptide +TARBP2<br />
 
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**[[3c4b]], [[3c4t]] – mDicer RNase III+dsRNA binding domains <br />
 
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**[[2l6m]] - Dicer residues 1259-1358 - fission yeast - NMR<br />
 
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**[[2ff1]] - Dicer - ''Giardia intestinalis''<br />
 
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*RNase 4
 
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**[[1wdy]] - hRNase 4 <br />
 
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**[[2rnf]], [[1rnf]], [[5ark]] - hRNase 4 + nucleotide<br />
 
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**[[5ar6]] - pRNase 4 - pig<br />
 
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**[[5arj]] - pRNase 4 (mutant)<br />
 
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**[[5arl]] - pRNase 4 (mutant) + nucleotide<br />
 
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**[[1kvz]] - BuRNase 4 - NMR<br />
 
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*RNase 5 or angiogenin
 
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**[[4aoh]] - hRNase 5 <br />
 
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**[[1un3]], [[1un4]], [[1un5]], [[1gv7]], [[4ahd]], [[4ahe]], [[4ahf]], [[4ahg]], [[4ahh]], [[4ahi]], [[4ahj]], [[4ahk]], [[4ahl]], [[4ahm]], [[4ahn]], [[5m9v]], [[5m9t]], [[5m9s]], [[5m9r]], [[5m9q]], [[5m9p]], [[5m9m]], [[5m9j]], [[5m9g]], [[5m9c]], [[5m9a]] - hRNase 5 (mutant)<br />
 
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**[[1h0d]] - hRNase 5 + antibody<br />
 
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**[[3lje]] - ZeRNase 5<br />
 
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*RNase 6
 
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**[[4x09]], [[6mv7]], [[6mv6]], [[5oab]], [[6enp]] - hRNase 6<br />
 
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**[[1oj1]], [[1oj8]] - BuRNase 6 + nucleotide<br />
 
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*RNase 7
 
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**[[2hky]] - hRNase 7 - NMR <br />
 
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*RNase B
 
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**[[1rbb]] - bRNase B <br />
 
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**[[1rbj]] - bRNase B + tetranucleotide <br />
 
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*RNase BA
 
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**[[1x1u]], [[1x1x]], [[1x1y]], [[1b27]], [[1b2u]], [[1b3s]], [[1x1w]] - BaRNase BA + barstar (mutant) - ''Bacillus amyloliquefaciens''<br />
 
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**[[3da7]], [[1brs]], [[1bgs]] - BaRNase BA + barstar <br />
 
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**[[1b2s]], [[2za4]] - BaRNase BA (mutant) + barstar (mutant) <br />
 
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**[[1brn]], [[2kf5]], [[2kf6]], [[1rnb]] - BaRNase BA + nucleotide<br />
 
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**[[3kch]], [[2f4y]], [[2f56]], [[2f5m]], [[2f5w]] - BaRNase BA crosslinked<br />
 
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**[[2kf3]], [[2kf4]], [[1fw7]], [[1bnr]] - BaRNase BA - NMR<br />
 
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**[[1yvs]], [[1b2x]], [[1a2p]], [[1bni]], [[1bnj]] - BaRNase BA <br />
 
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**[[1b20]], [[1b21]], [[1b2z]], [[1bne]], [[1bnf]], [[1bng]], [[1brh]], [[1bri]], [[1brj]], [[1brk]], [[1bns]], [[1brg]], [[1bsa]], [[1bsb]], [[1bsc]], [[1bsd]], [[1bse]], [[1bna]], [[1bao]] - BaRNase BA (mutant)<br />
 
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*RAase D
 
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**[[1yt3]] - EcRNase D<br />
 
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*RNase E; Domains: recognition 1-28; S1 35-125; catalytic 1-515
 
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**[[2vmk]], [[2c4r]], [[2bx2]] - EcRNase E catalytic domain<br />
 
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**[[1slj]] - EcRNase E S1 domain - NMR<br />
 
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**[[1smx]], [[1sn8]] - EcRNase E S1 domain <br />
 
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**[[2vrt]], [[2c0b]] - EcRNase E catalytic domain + RNA<br />
 
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**[[5f6c]], [[6g63]] - EcRNase E catalytic domain (mutant) + RNA<br />
 
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**[[3h8a]] - EcRNase E recognition domain + enolase<br />
 
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**[[5ohg]] - EcRNase E residues 813-850 + enolase<br />
 
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**[[4oxp]] - CcRNase E S1+ sensor domains – ''Caulobacter crescentus'' <br />
 
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*RNase F1
 
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**[[1fus]], [[1fut]] - GfRNase F1 + nucleotide - ''Gibberella fujikuroi''<br />
 
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**[[1rck]], [[1rci]] - GfRNase F1 - NMR<br />
 
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*RNase H
 
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**[[3h7i]], [[3h8s]], [[3h8w]] - T4RNase H (mutant) - Enterobacteria phage T4<br />
 
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**[[2ihn]] - T4RNase H (mutant) + DNA<br />
 
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**[[3h8j]], [[1tfr]] - T4RNase H <br />
 
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**[[4e89]] - RNase H - XMRV<br />
 
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**[[4ly7]] - RNase H - ancestral<br />
 
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**[[2rpi]], [[1ril]] - TtRNase H - ''Thermus thermophilus''<br />
 
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**[[1rbr]], [[1rbs]], [[1rbt]], [[1rbu]], [[1rbv]], [[2rn2]] - EcRNase H <br />
 
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**[[1lav]], [[1law]], [[1rda]], [[1rdb]], [[1rdc]] - EcRNase H (mutant) <br />
 
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**[[1jl2]] - EcRNase H/TtRNase H <br />
 
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**[[4z0u]] - EcRNase H + peptide<br />
 
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**[[3d0p]], [[3ey1]], [[3i8d]], [[4opj]], [[4opk]], [[5swm]] - BhRNase H (mutant) + DNA - ''Bacillus halodurans''<br />
 
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**[[1zbf]] - BhRNase H (mutant) <br />
 
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**[[6dpp]], [[6dpo]], [[6dpn]], [[6dpm]], [[6dpl]], [[6dpk]], [[6dpj]], [[6dpi]], [[6dpg]], [[6dph]], [[6dpf]], [[6dpe]], [[6dpd]], [[6dpc]], [[6dpb]], [[6dpa]], [[6dp9]], [[6dp8]] [[6dp7]], [[6dp6]], [[6dp5]], [[6dp4]], [[6dp3]], [[6dp2]], [[6dp1]], [[6dp0]], [[6doz]], [[6doy]], [[6dox]], [[6dow]], [[6dov]], [[6dou]], [[6dot]], [[6dos]], [[6dor]], [[6doq]], [[6dop]], [[6doo]], [[6don]], [[6dom]], [[6dol]], [[6dok]], [[6doj]], [[6doi]], [[6doh]], [[6dog]], [[6dof]], [[6doe]], [[6dod]], [[6doc]], [[6dob]], [[6doa]], [[6do9]], [[6do8]], [[6dmv]], [[6dmn]] - BhRNase H + RNA + DNA<br />
 
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**[[2r7y]], [[2g8f]], [[2g8h]], [[2g8i]], [[2g8k]], [[2g8u]], [[2g8v]], [[2g8w]], [[1zbi]], [[1zbl]], [[3twh]], [[3uld]], [[5us2]], [[5usa]], [[5use]], [[5usg]], [[5w7n]], [[5w7o]], [[5wjr]] - BhRNase H (mutant) + RNA + DNA<br />
 
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**[[4htu]], [[4hue]], [[4huf]], [[4hug]] - BhRNase H + DNA<br />
 
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**[[4ibn]] - uRNase H - uncultured<br />
 
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**[[4h8k]] - uRNase H + RNA + DNA<br />
 
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**[[4e7h]], [[4e7i]], [[4e7j]], [[4e7k]], [[4e7l]] - RNase H + DNA – human spumaretrovirus<br />
 
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*RNase HI
 
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**[[3bsu]] - hRNase HI catalytic domain + RNA + DNA<br />
 
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**[[2qk9]], [[2qkb]], [[2qkk]] - hRNase HI (mutant) + RNA + DNA<br />
 
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**[[1qhk]] - yRNase HI N terminal - NMR<br />
 
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**[[3h08]] - RNase HI - ''Chlorobaculum tepidum''<br />
 
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**[[3aa2]], [[3aa3]], [[3aa4]], [[3aa5]], [[2yv0]], [[2z1g]], [[2z1h]], [[2z1i]], [[2z1j]], [[1wse]], [[1wsf]], [[1wsg]], [[1wsh]], [[1wsi]], [[1wsj]], [[1jxb]], [[1jl1]], [[1f21]], [[1kva]], [[1kvb]], [[1kvc]], [[1goa]], [[1gob]], [[1goc]] - EcRNase HI (mutant) <br />
 
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**[[1g15]], [[1rdd]], [[1rnh]] - EcRNase HI <br />
 
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**[[1rch]] - EcRNase HI - NMR <br />
 
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**[[2zqb]] - SoRNase HI (mutant) - ''Shewanella oneidensis''<br />
 
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**[[2e4l]] - SoRNase HI <br />
 
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**[[2ehg]] - RNase HI - ''Sulfolobus tokodaii''<br />
 
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**[[3u3g]] - uRNase HI<br />
 
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**[[4e19]], [[4nyn]] - RNase HI - ''Halobacterium salinarium''<br />
 
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*RNase HII
 
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**[[3puf]], [[3p56]], [[3p5j]] - hRNase HII subunits α+β+γ<br />
 
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**[[3kio]] - mRNase HII subunits α+β+γ <br />
 
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**[[3p83]] - AfRNase HII + DNA polymerase sliding clamp - ''Archaeoglobus fulgidus''<br />
 
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**[[1i39]], [[1i3a]] - AfRNase HII <br />
 
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**[[3o3g]] - TmRNase HII + DNA<br />
 
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**[[3o3f]], [[3o3h]], [[4hht]] - TmRNase HII (mutant) + DNA<br />
 
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**[[2etj]] - TmRNase HII <br />
 
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**[[1x1p]], [[1io2]] - TkRNase HII - ''Thermococcus kodakarensis''<br />
 
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**[[2dfe]], [[2dff]], [[2dfh]] - TkRNase HII (mutant) <br />
 
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**[[1eke]] - MjRNase HII - ''Methanocaldococcus jannaschii''<br />
 
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**[[5y9p]] - SaRNase HII - ''Staphylococcus aureus''<br />
 
- 
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*RNase HIII
 
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**[[2d0a]], [[2d0b]], [[2d0c]] - GsRNase HIII - ''Geobacillus stearothermophilus''<br />
 
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**[[3asm]] - GsRNase HIII (mutant) <br />
 
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**[[1uax]] - PhRNase HIII - ''Pyrococcus horikoshii'' <br />
 
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**[[3vn5]] - AaRNase HIII <br />
 
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**[[4py5]] - RNase HIII + RNA + DNA – ''Thermovibrio ammonificans''<br />
 
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*RNase J
 
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**[[3bk1]] - TtRNase J <br />
 
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**[[3bk2]] - TtRNase J + nucleotide<br />
 
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**[[3zq4]] - BsRNase J1 - ''Bacillus subtilis'' <br />
 
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**[[5haa]] - MpRNase - ''Methanolobus psychrophilus''<br />
 
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**[[5hab]], [[5ws2]] - MpRNase (mutant) + RNA<br />
 
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**[[4xwt]] - DrRNase J + nucleotide - ''Deinococcus radiodurans''<br />
 
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**[[4xww]] - DrRNase J + RNA<br />
 
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**[[5a0t]], [[5a0v]] - RNase J + RNA - ''Streptomyces coelicolor''<br />
 
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**[[5vaj]] - BhRNase J + RNA + DNA<br />
 
- 
-
*RNase K6
 
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**[[5oab]] - hRNase K6 <br />
 
- 
-
*RNase L
 
- 
-
**[[4o1o]] - pRNase L + oligoadenylate + CMP - pig <br />
 
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**[[4o1p]] - pRNase L + oligoadenylate + AMPPNP <br />
 
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**[[4oav]] - pRNase L + oligoadenylate + AMPPCP + RNA<br />
 
- 
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*RNase LE
 
- 
-
**[[1dix]] - RNase LE - ''Solanum lycopersicum''<br />
 
- 
-
*RNase MAR1
 
- 
-
**[[1xn4]] - RNase MAR1 - ''Leishmania major''<br />
 
-
**[[2b34]] - RNase MAR1 - ''Caenorhabditis elegans''<br />
 
- 
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*RNase MS
 
- 
-
**[[1rms]], [[1rds]] - RNase MS - ''Aspergillus phoenicis''<br />
 
- 
-
*RNase MC1
 
- 
-
**[[1v9h]], [[1j1f]], [[1j1g]] - McRNase MC1 (mutant) + nucleotide - ''Momordica charantia''<br />
 
-
**[[1ucg]] - McRNase MC1 (mutant) <br />
 
-
**[[1uca]], [[1ucc]], [[1ucd]] - McRNase MC1 + nucleotide <br />
 
-
**[[1bk7]] - McRNase MC1 <br />
 
- 
-
*RNase NT
 
- 
-
**[[1vcz]], [[1vd1]], [[1vd3]] - NgRNase NT + nucleotide - ''Nicotiana glutinosa''<br />
 
-
**[[1iyb]] - NgRNase NW <br />
 
- 
-
*RNase P
 
- 
-
**[[4xgl]], [[4xgm]] - hRNase P<br />
 
-
**[[6ahr]] - hRNase P – cryo EM<br />
 
-
**[[6ahu]] - hRNase P + tRNA – cryo EM<br />
 
-
**[[5nfj]] - hRNase P protein 1 + SAM<br />
 
-
**[[6cwx]] - hRNase P subunits P20+P25 <br />
 
-
**[[6ahv]] - hRNase P subunit P40 <br />
 
-
**[[6agb]] - yRNase P – cryo EM<br />
 
-
**[[6ah3]] - yRNase P + tRNA + RNA – cryo EM<br />
 
-
**[[3iab]] - yRNase P subunits POP6+POP7 + RNase MRP P3 domain<br />
 
-
**[[1nz0]] - TmRNase P <br />
 
-
**[[6max]] - TmRNase P + purpurin <br />
 
-
**[[6cqc]] - TmRNase P + inhibitor<br />
 
-
**[[3q1q]], [[3q1r]] - TmRNase P + TmRNase P RNA + tRNAPhe <br />
 
-
**[[1d6t]], [[6d1r]] - SaRNase P <br />
 
-
**[[2a64]] - GsRNase P (mutant) <br />
 
-
**[[1a6f]], [[1nbs]], [[2jg4]] - BsRNase P (mutant) <br />
 
-
**[[1ts9]], [[1tsf]] - AfRNase P <br />
 
-
**[[1u9s]] - RNase P - synthetic <br />
 
-
**[[2avs]] - PfRNase P (mutant) - ''Pyrococcus furiosus'' <br />
 
-
**[[2k3r]]. [[2ki7]] - PfRNase P <br />
 
-
**[[2ljp]] - EcRNase P <br />
 
-
**[[2av5]] - PhRNase P component 2<br />
 
-
**[[1x0t]] - PhRNase P component 4<br />
 
-
**[[2zae]] - PhRNase P components 1+4<br />
 
-
**[[2czv]] - PhRNase P component 2 (mutant) +3<br />
 
-
**[[6k0a]] - MjRNase P components 1-4 + L7AE + RPR – Cryo EM<br />
 
-
**[[6k0b]] - MjRNase P components 1-4 + L7AE + tRNA + RPR – Cryo EM<br />
 
-
**[[5diz]], [[5ft9]] - RNase P2 - ''Arabidopsis thaliana''<br />
 
- 
-
*RNase PH
 
- 
-
**[[3dd6]] - RNase PH - ''Bacillus anthracis'' <br />
 
-
**[[1oyp]], [[1oyr]], [[1oys]] - BsRNase PH <br />
 
-
**[[1r6l]], [[1r6m]] - PaRNase PH - ''Pseudomonas aeruginosa''<br />
 
-
**[[3b4t]] - MtRNase PH <br />
 
-
**[[1udn]] - AaRNase PH <br />
 
-
**[[1udo]], [[1udq]], [[1uds]] - AaRNase PH (mutant)<br />
 
- 
-
*RNase PO1
 
- 
-
**[[3who]] - omRNase PO1 – oyster mushroom <br />
 
-
**[[3wr2]] - omRNase PO1 + nucleotide <br />
 
- 
-
*RNase R
 
- 
-
**[[5xgu]] - EcRNase R (mutant) <br />
 
- 
-
*RNase RH
 
- 
-
**[[1bol]] - RNase RH - ''Rhizopus niveus'' <br />
 
- 
-
*RNase S
 
- 
-
**[[3oqy]], [[3oqz]], [[3or0]], [[1z3l]], [[1z3m]], [[1z3p]], [[1y92]], [[1y94]], [[1fev]], [[1d5d]], [[1d5e]], [[1d5h]], [[2rln]], [[1qwq]], [[4n4c]] - bRNase S seminal (mutant) <br />
 
-
**[[1tq9]], [[1r5c]], [[11ba]], [[11bg]] - bRNase S + nucleotide <br />
 
-
**[[1r5d]], [[1r3m]], [[1n1x]], [[1n3z]], [[1j7z]], [[1j80]], [[1j81]], [[1j82]], [[1cjq]], [[1cjr]], [[1bsr]], [[1rbc]], [[1rbd]], [[1rbe]], [[1rbf]], [[1rbg]], [[1rbh]], [[1rbi]], [[1rnu]], [[1rnv]], [[2rns]] - bRNase S <br />
 
-
**[[1b6v]] - bRNase S/bRNase A <br />
 
-
**[[4ygw]] - bRNase S + peptide<br />
 
- 
-
*RNase S3
 
- 
-
**[[1iqq]] - RNase S3 - Japanese pear <br />
 
- 
-
*RNase SA
 
- 
-
**[[3a5e]], [[1zgx]], [[1ynv]], [[1t2h]], [[1t2i]], [[1uci]], [[1ucj]], [[1uck]], [[1ucl]], [[1i70]], [[1i8v]], [[1box]], [[4gho]], [[4j5g]], [[4j5k]] - SaRNase SA guanyl-specific (mutant) - ''Streptomyces aureofaciens'' <br />
 
-
**[[1lni]], [[1c54]], [[1rge]], [[1rgf]], [[1rgg]], [[1rgh]], [[1sar]] - SaRNase SA <br />
 
-
**[[1gmp]], [[1gmq]], [[1gmr]], [[2sar]] - SaRNase SA + nucleotide <br />
 
-
**[[1ay7]] - SaRNase SA + barstar <br />
 
-
**[[1rsn]] - SaRNase SA + cyclophosphothiolate <br />
 
-
**[[1py3]], [[1pyl]] - SaRNase SA2 <br />
 
-
**[[3dgy]], [[3dh2]], [[3d4a]], [[3d5g]], [[3d5i]] - SaRNase SA2 + nucleotide <br />
 
-
**[[1mgr]], [[1mgw]] - SaRNase SA3 <br />
 
- 
-
*RNase SF11
 
- 
-
**[[1ioo]] - RNase SF11 - ''Nicotiana alata'' <br />
 
- 
-
*RNase T
 
- 
-
**[[2is3]] - EcRNase T <br />
 
-
**[[3ngy]] - EcRNase T (mutant)<br />
 
-
**[[3ngz]] - EcRNase T (mutant) + nucleotide<br />
 
-
**[[3ngo]], [[3nh1]], [[3nh2]] - EcRNase T + nucleotide<br />
 
-
**[[3v9s]], [[3v9w]], [[3v9u]], [[3v9x]], [[3v9z]], [[3va0]], [[3va3]], [[4kaz]], [[4kb0]], [[4kb1]], [[3nh0]] - EcRNase T + DNA<br />
 
-
**[[2f96]] - PaRNase T <br />
 
- 
-
*RNase T1
 
- 
-
**[[1tto]], [[1rn1]], [[1rn4]], [[1rnt]], [[2aad]], [[2aae]] - AoRNase T1 - ''Aspergillus oryzae'' <br />
 
-
**[[1q9e]], [[1iyy]], [[1i2e]], [[1i2f]], [[1i2g]], [[1i3f]], [[1i3i]], [[1hz1]], [[1fys]], [[1fzu]], [[1ch0]], [[4bir]], [[3bir]], [[5bir]], [[1g02]], [[1hyf]], [[1trp]], [[1trq]], [[2bir]], [[4rnt]], [[5rnt]], [[6rnt]], [[7rnt]], [[8rnt]], [[9rnt]] - AoRNase T1 (mutant)<br />
 
-
**[[1lov]], [[1low]], [[1loy]], [[1i0v]], [[1i0x]], [[1b2m]], [[1rhl]], [[1bir]], [[1rgk]], [[1rgl]], [[5hoh]] - AoRNase T1 (mutant) + nucleotide<br />
 
-
**[[1bvi]], [[2bu4]], [[2hoh]], [[3hoh]], [[4hoh]], [[5hoh]], [[1gsp]], [[2gsp]]. [[3gsp]], [[4gsp]], [[5gsp]]. [[6gsp]], [[7gsp]], [[1det]], [[1rls]], [[1lra]], [[1rga]], [[1bu4]], [[1rgc]], [[3bu4]], [[4bu4]], [[5bu4]], [[3syu]], [[3urp]], [[2rnt]], [[6gsp]] - AoRNase T1 + nucleotide<br />
 
-
**[[3rnt]] - AoRNase T1 + V<br />
 
-
**[[1ygw]] - AoRNase T1 - NMR<br />
 
-
**[[5gy6]] - hRNase T1 - ''Hericium erinaceus''<br />
 
- 
-
*RNase T2
 
- 
-
**[[3t0o]] - hRNase T2<br />
 
- 
-
*RNase U2
 
- 
-
**[[3agn]], [[3ago]], [[3ahw]] - UsRNase U2 + AMP - ''Ustilago sphaerogena''<br />
 
-
**[[1rtu]] - UsRNase U2<br />
 
-
**[[3ahs]] - UsRNase U2B<br />
 
- 
-
*RNase VAP
 
- 
-
**[[6a7v]] - MtRNase C11 + B11<br />
 
-
**[[5x3t]] - MtRNase C26 + B26<br />
 
-
**[[6wzf]], [[5wz4]] - MtRNase C20<br />
 
-
**[[5sv2]] - MtRNase C21<br />
 
-
**[[5l6m]], [[5k8j]] - CcRNase C + B<br />
 
-
**[[5l6l]] - CcRNase C + B + DNA<br />
 
-
**[[5h4h]], [[5h4g]] - PhRNase C4<br />
 
- 
-
*RNase Z
 
- 
-
**[[3v32]], [[3v33]], [[3v34]] - hRNase Z<br />
 
-
**[[5mtz]] - yRNase Z<br />
 
-
**[[2e7y]] - TmRNase Z<br />
 
-
**[[2fk6]], [[4gcw]] - BsRNase Z (mutant) + tRNA Thr<br />
 
-
**[[1y44]] - BsRNase Z (mutant) <br />
 
-
**[[2cbn]] - EcRNase Z<br />
 
- 
-
*RNase ZC3H12A
 
- 
-
**[[5h9v]], [[5h9w]] - mRNase ZC PIN domain<br />
 
- 
-
*RNase α-sarcin
 
- 
-
**[[1de3]] - AgRNase αs - ''Aspergillus giganteus''<br />
 
-
**[[1r4y]] - AgRNase αs (mutant)<br />
 
- 
-
*Oligoribonuclease
 
- 
-
**[[2igi]], [[1yta]] - EcORNase<br />
 
-
**[[2gbz]] - ORNase - ''Xanthomonas campestris''<br />
 
-
**[[1j9a]] - HiORNase - ''Haemophilus influenza''<br />
 
-
**[[6nkl]] - HiORNase + VAPB1<br />
 
-
**[[3tr8]] - CbORNase - ''Coxiella burnetii''<br />
 
-
**[[5cy4]] - ORNase - ''Acinetobacter baumannii''<br />
 
- 
-
*NanoRNase or bifunctional oligoribonuclease and PAP phosphatase nRNA
 
- 
-
**[[5j21]] - BsNNase - ''Bacillus subtilis''<br />
 
-
**[[5ipp]], [[5iuf]] - BsNNase (mutant) + nucleotide <br />
 
-
**[[5izo]] - BsNNase (mutant) <br />
 
-
**[[5cet]] - MtNNase <br />
 
- 
-
*Polynucleotide phosphorylase
 
- 
-
**[[3cdi]] - EcPNPase<br />
 
-
**[[3gll]] - EcPNPase core<br />
 
-
**[[3cdj]] - EcPNPase C terminal truncated<br />
 
-
**[[1sro]] - EcPNPase RNA-binding domain - NMR<br />
 
-
**[[3gcm]], [[3gme]], [[3h1c]] - EcPNPase + RNase E recognition domain<br />
 
-
**[[1e3h]], [[1e3p]] - PNPase - ''Streptomyces antibioticus''<br />
 
-
**[[3h36]] - PNPase fragment - ''Streptomyces mutans''<br />
 
-
**[[4nbq]] - CbPNPase<br />
 
-
**[[4am3]] - PNPase + RNA - ''Caulobacter vibrioides''<br />
 
- 
-
*Binase
 
- 
-
**[[1gou]], [[1gov]], [[1goy]] - BiBinase - ''Bacillus intermedius''<br />
 
-
**[[2rbi]], [[4haa]] - BiBinase (mutant)<br />
 
-
**[[1buj]] - BiBinase - NMR<br />
 
- 
-
*Poly(A)-specific RNase
 
- 
-
**[[2a1s]] - hParn <br />
 
-
**[[2a1r]], [[3ctr]] - hParn + nucleotide<br />
 
-
**[[1ug8]] - mParn R3H domain - NMR<br />
 
-
**[[1whv]] - mParn RNA-binding domain - NMR<br />
 
-
**[[2rok]] - mParn CAP-binding domain - NMR<br />
 
-
**[[3d45]] - mParn + nucleotide<br />
 
-
**[[4q8g]], [[4q8h]] - yParn catalytic subunit <br />
 
-
**[[4xr7]] - yParn regulatory+catalytic subunits<br />
 
-
**[[4bwk]] - NcParn regulatory subunit – ''Neurospora crassa''<br />
 
-
**[[4bwx]] - NcParn regulatory subunit (mutant)<br />
 
-
**[[4czv]], [[4czw]] - NcParn catalytic subunit <br />
 
-
**[[4czx]], [[4czy]] - NcParn regulatory+catalytic subunits<br />
 
-
**[[4bwp]] - Parn regulatory subunit – ''Drosophila melanogaster''<br />
 
- 
-
*RNase pop2
 
- 
-
**[[4b8a]] - yRNase pop2 + cell division cycle protein 39<br />
 
-
**[[4b8c]] - yRNase pop2 + cell division cycle protein 39 + CCR4<br />
 
- 
-
*Other RNases
 
- 
-
**[[2zpo]] - RNase - ''Chelonia mydas''<br />
 
-
**[[3a4y]], [[3idz]], [[3ie0]], [[3ie2]] - TtRNase (mutant) - ''Thermus thermophilus''<br />
 
-
**[[3iek]] - TtRNase<br />
 
-
**[[3ie1]], [[3iem]] - TtRNase (mutant)<br />
 
-
**[[3iel]] - TtRNase + nucleotide<br />
 
-
**[[6of4]], [[6of3]], [[6of2]] - RNase + Clp1_P domain-containing protein - ''Chaetomium thermophilum''<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribonuclease A (magenta) complex with thymidylic acid DNA tetramer (pink), 1rta

Drag the structure with the mouse to rotate

References

  1. ↑ Cho S, Beintema JJ, Zhang J. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics. 2005 Feb;85(2):208-20. PMID:15676279 doi:http://dx.doi.org/10.1016/j.ygeno.2004.10.008
  2. ↑ Cudny H, Zaniewski R, Deutscher MP. Escherichia coli RNase D. Catalytic properties and substrate specificity. J Biol Chem. 1981 Jun 10;256(11):5633-7. PMID:6263886
  3. ↑ Moelling K, Broecker F, Kerrigan JE. RNase H: specificity, mechanisms of action, and antiviral target. Methods Mol Biol. 2014;1087:71-84. doi: 10.1007/978-1-62703-670-2_7. PMID:24158815 doi:http://dx.doi.org/10.1007/978-1-62703-670-2_7
  4. ↑ Lu F, Taghbalout A. The Escherichia coli major exoribonuclease RNase II is a component of the RNA degradosome. Biosci Rep. 2014 Dec 23;34(6):e00166. doi: 10.1042/BSR20140113. PMID:25299745 doi:http://dx.doi.org/10.1042/BSR20140113
  5. ↑ PMID:24124o76
  6. ↑ Ji X. The mechanism of RNase III action: how dicer dices. Curr Top Microbiol Immunol. 2008;320:99-116. PMID:18268841
  7. ↑ Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Ruth FX, Coll M. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 8;285(1):205-14. PMID:9878400 doi:10.1006/jmbi.1998.2288
  8. ↑ Kim KW, Park SH, Oh DH, Lee SH, Lim KS, Joo K, Chun YS, Chang SI, Min KM, Kim JC. Ribonuclease 5 coordinates signals for the regulation of intraocular pressure and inhibits neural apoptosis as a novel multi-functional anti-glaucomatous strategy. Biochim Biophys Acta. 2016 Feb;1862(2):145-54. doi: 10.1016/j.bbadis.2015.11.005., Epub 2015 Nov 12. PMID:26581172 doi:http://dx.doi.org/10.1016/j.bbadis.2015.11.005
  9. ↑ Prats-Ejarque G, Arranz-Trullen J, Blanco JA, Pulido D, Nogues MV, Moussaoui M, Boix E. The first crystal structure of human RNase6 reveals a novel substrate binding and cleavage site arrangement. Biochem J. 2016 Mar 24. pii: BCJ20160245. PMID:27013146 doi:http://dx.doi.org/10.1042/BCJ20160245
  10. ↑ Harder J, Schroder JM. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem. 2002 Nov 29;277(48):46779-84. Epub 2002 Sep 18. PMID:12244054 doi:http://dx.doi.org/10.1074/jbc.M207587200
  11. ↑ Mackie GA. RNase E: at the interface of bacterial RNA processing and decay. Nat Rev Microbiol. 2013 Jan;11(1):45-57. doi: 10.1038/nrmicro2930. PMID:23241849 doi:http://dx.doi.org/10.1038/nrmicro2930
  12. ↑ Condon C. What is the role of RNase J in mRNA turnover? RNA Biol. 2010 May-Jun;7(3):316-21. Epub 2010 May 26. PMID:20458164
  13. ↑ Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH. RNase L activates the NLRP3 inflammasome during viral infections. Cell Host Microbe. 2015 Apr 8;17(4):466-77. doi: 10.1016/j.chom.2015.02.010. Epub, 2015 Mar 26. PMID:25816776 doi:http://dx.doi.org/10.1016/j.chom.2015.02.010
  14. ↑ Suzuki A, Yao M, Tanaka I, Numata T, Kikukawa S, Yamasaki N, Kimura M. Crystal structures of the ribonuclease MC1 from bitter gourd seeds, complexed with 2'-UMP or 3'-UMP, reveal structural basis for uridine specificity. Biochem Biophys Res Commun. 2000 Aug 28;275(2):572-6. PMID:10964705 doi:10.1006/bbrc.2000.3318
  15. ↑ Potuschak T, Rossmanith W, Karwan R. RNase MRP and RNase P share a common substrate. Nucleic Acids Res. 1993 Jul 11;21(14):3239-43. doi: 10.1093/nar/21.14.3239. PMID:7688115 doi:http://dx.doi.org/10.1093/nar/21.14.3239
  16. ↑ Mann H, Ben-Asouli Y, Schein A, Moussa S, Jarrous N. Eukaryotic RNase P: role of RNA and protein subunits of a primordial catalytic ribonucleoprotein in RNA-based catalysis. Mol Cell. 2003 Oct;12(4):925-35. PMID:14580343
  17. ↑ Deutscher MP, Marshall GT, Cudny H. RNase PH: an Escherichia coli phosphate-dependent nuclease distinct from polynucleotide phosphorylase. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4710-4. PMID:2455297
  18. ↑ Daugeron MC, Mauxion F, Seraphin B. The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res. 2001 Jun 15;29(12):2448-55. PMID:11410650
  19. ↑ Kurihara H, Mitsui Y, Ohgi K, Irie M, Mizuno H, Nakamura KT. Crystal and molecular structure of RNase Rh, a new class of microbial ribonuclease from Rhizopus niveus. FEBS Lett. 1992 Jul 20;306(2-3):189-92. PMID:1633875
  20. ↑ Shaw KL, Grimsley GR, Yakovlev GI, Makarov AA, Pace CN. The effect of net charge on the solubility, activity, and stability of ribonuclease Sa. Protein Sci. 2001 Jun;10(6):1206-15. PMID:11369859 doi:http://dx.doi.org/10.1110/ps.440101
  21. ↑ Hsiao YY, Fang WH, Lee CC, Chen YP, Yuan HS. Structural insights into DNA repair by RNase T--an exonuclease processing 3' end of structured DNA in repair pathways. PLoS Biol. 2014 Mar 4;12(3):e1001803. doi: 10.1371/journal.pbio.1001803., eCollection 2014 Mar. PMID:24594808 doi:http://dx.doi.org/10.1371/journal.pbio.1001803
  22. ↑ Loverix S, Winqvist A, Stromberg R, Steyaert J. Mechanism of RNase T1: concerted triester-like phosphoryl transfer via a catalytic three-centered hydrogen bond. Chem Biol. 2000 Aug;7(8):651-8. PMID:11048955
  23. ↑ Noguchi S. Isomerization mechanism of aspartate to isoaspartate implied by structures of Ustilago sphaerogena ribonuclease U2 complexed with adenosine 3'-monophosphate. Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):843-9. Epub 2010 Jun 19. PMID:20606265 doi:10.1107/S0907444910019621
  24. ↑ Pellegrini O, Nezzar J, Marchfelder A, Putzer H, Condon C. Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis. EMBO J. 2003 Sep 1;22(17):4534-43. PMID:12941704 doi:http://dx.doi.org/10.1093/emboj/cdg435
  25. ↑ Sylvester ID, Roberts LM, Lord JM. Characterization of prokaryotic recombinant Aspergillus ribotoxin alpha-sarcin. Biochim Biophys Acta. 1997 Aug 21;1358(1):53-60. PMID:9296521
  26. ↑ Datta AK, Niyogi K. A novel oligoribonuclease of Escherichia coli. II. Mechanism of action. J Biol Chem. 1975 Sep 25;250(18):7313-9. PMID:170260
  27. ↑ Yehudai-Resheff S, Hirsh M, Schuster G. Polynucleotide phosphorylase functions as both an exonuclease and a poly(A) polymerase in spinach chloroplasts. Mol Cell Biol. 2001 Aug;21(16):5408-16. PMID:11463823 doi:http://dx.doi.org/10.1128/MCB.21.16.5408-5416.2001
  28. ↑ Dudkina E, Kayumov A, Ulyanova V, Ilinskaya O. New insight into secreted ribonuclease structure: binase is a natural dimer. PLoS One. 2014 Dec 31;9(12):e115818. doi: 10.1371/journal.pone.0115818., eCollection 2014. PMID:25551440 doi:http://dx.doi.org/10.1371/journal.pone.0115818
  29. ↑ Hirayama T, Matsuura T, Ushiyama S, Narusaka M, Kurihara Y, Yasuda M, Ohtani M, Seki M, Demura T, Nakashita H, Narusaka Y, Hayashi S. A poly(A)-specific ribonuclease directly regulates the poly(A) status of mitochondrial mRNA in Arabidopsis. Nat Commun. 2013;4:2247. doi: 10.1038/ncomms3247. PMID:23912222 doi:http://dx.doi.org/10.1038/ncomms3247
  30. ↑ Schmier BJ, Nelersa CM, Malhotra A. Structural Basis for the Bidirectional Activity of Bacillus nanoRNase NrnA. Sci Rep. 2017 Sep 11;7(1):11085. doi: 10.1038/s41598-017-09403-x. PMID:28894100 doi:http://dx.doi.org/10.1038/s41598-017-09403-x
  31. ↑ Lai LB, Chan PP, Cozen AE, Bernick DL, Brown JW, Gopalan V, Lowe TM. Discovery of a minimal form of RNase P in Pyrobaculum. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22493-8. PMID:21135215 doi:10.1073/pnas.1013969107
  32. ↑ OLSON BH, GOERNER GL. ALPHA SARCIN, A NEW ANTITUMOR AGENT. I. ISOLATION, PURIFICATION, CHEMICAL COMPOSITION, AND THE IDENTITY OF A NEW AMINO ACID. Appl Microbiol. 1965 May;13:314-21. PMID:14325268
  33. ↑ Makarov AA, Kolchinsky A, Ilinskaya ON. Binase and other microbial RNases as potential anticancer agents. Bioessays. 2008 Aug;30(8):781-90. doi: 10.1002/bies.20789. PMID:18623073 doi:http://dx.doi.org/10.1002/bies.20789
  34. ↑ Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int. 2015 Jan;87(1):151-61. doi: 10.1038/ki.2014.268. Epub 2014 Jul 30. PMID:25075772 doi:http://dx.doi.org/10.1038/ki.2014.268
  35. ↑ Scherbik SV, Paranjape JM, Stockman BM, Silverman RH, Brinton MA. RNase L plays a role in the antiviral response to West Nile virus. J Virol. 2006 Mar;80(6):2987-99. PMID:16501108 doi:http://dx.doi.org/10.1128/JVI.80.6.2987-2999.2006
  36. ↑ Kobayashi H, Motoyoshi N, Itagaki T, Tabata K, Suzuki T, Inokuchi N. The inhibition of human tumor cell proliferation by RNase Pol, a member of the RNase T1 family, from Pleurotus ostreatus. Biosci Biotechnol Biochem. 2013;77(7):1486-91. Epub 2013 Jul 7. PMID:23832341 doi:http://dx.doi.org/10.1271/bbb.130133
  37. ↑ Thorn A, Steinfeld R, Ziegenbein M, Grapp M, Hsiao HH, Urlaub H, Sheldrick GM, Gartner J, Kratzner R. Structure and activity of the only human RNase T2. Nucleic Acids Res. 2012 Jun 26. PMID:22735700 doi:10.1093/nar/gks614
  38. ↑ Acquati F, Lualdi M, Bertilaccio S, Monti L, Turconi G, Fabbri M, Grimaldi A, Anselmo A, Inforzato A, Collotta A, Cimetti L, Riva C, Gribaldo L, Ghia P, Taramelli R. Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8140-5. doi:, 10.1073/pnas.1222079110. Epub 2013 Apr 29. PMID:23630276 doi:http://dx.doi.org/10.1073/pnas.1222079110
  39. ↑ Birdsall DL, McPherson A. Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A. J Biol Chem. 1992 Nov 5;267(31):22230-6. PMID:1429575
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