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6tnb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 41== | |
| + | <StructureSection load='6tnb' size='340' side='right'caption='[[6tnb]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6tnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QW:(2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide'>8QW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnb OCA], [https://pdbe.org/6tnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tnb RCSB], [https://www.ebi.ac.uk/pdbsum/6tnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bader B]] | ||
| + | [[Category: Boemer U]] | ||
| + | [[Category: Bohlmann R]] | ||
| + | [[Category: Brands M]] | ||
| + | [[Category: Briem H]] | ||
| + | [[Category: Eberspaecher U]] | ||
| + | [[Category: Fernandez-Montalvan A]] | ||
| + | [[Category: Holton SJ]] | ||
| + | [[Category: Klar U]] | ||
| + | [[Category: Koppitz M]] | ||
| + | [[Category: Kosemund D]] | ||
| + | [[Category: Marquardt T]] | ||
| + | [[Category: Nguyen D]] | ||
| + | [[Category: Nussbaum F]] | ||
| + | [[Category: Prechtl S]] | ||
| + | [[Category: Schirok H]] | ||
| + | [[Category: Schulze VK]] | ||
| + | [[Category: Siemeister G]] | ||
Current revision
X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 41
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Categories: Homo sapiens | Large Structures | Bader B | Boemer U | Bohlmann R | Brands M | Briem H | Eberspaecher U | Fernandez-Montalvan A | Holton SJ | Klar U | Koppitz M | Kosemund D | Marquardt T | Nguyen D | Nussbaum F | Prechtl S | Schirok H | Schulze VK | Siemeister G
