5qiw

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<StructureSection load='5qiw' size='340' side='right'caption='[[5qiw]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
<StructureSection load='5qiw' size='340' side='right'caption='[[5qiw]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qiw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QIW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5qiw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QIW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=J5S:N-[(E)-(4-methylphenyl)methylidene]acetamide'>J5S</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=J5S:(~{N}~{E})-~{N}-[(4-methylphenyl)methylidene]ethanamide'>J5S</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qiw OCA], [http://pdbe.org/5qiw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qiw RCSB], [http://www.ebi.ac.uk/pdbsum/5qiw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qiw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qiw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qiw OCA], [https://pdbe.org/5qiw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qiw RCSB], [https://www.ebi.ac.uk/pdbsum/5qiw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qiw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
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[https://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Bradley AR]]
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[[Category: Bradley, A R]]
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[[Category: Brandao-Neto J]]
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[[Category: Brandao-Neto, J]]
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[[Category: Collins P]]
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[[Category: Collins, P]]
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[[Category: Douangamath A]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Douangamath, A]]
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[[Category: Krojer T]]
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[[Category: Edwards, A]]
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[[Category: London N]]
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[[Category: Krojer, T]]
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[[Category: Resnick E]]
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[[Category: London, N]]
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[[Category: Sethi R]]
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[[Category: Resnick, E]]
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[[Category: Talon R]]
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[[Category: Sethi, R]]
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[[Category: Von Delft F]]
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[[Category: Talon, R]]
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[[Category: Deubiquitinating enzyme otub2]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease otub2]]
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[[Category: Sgc - diamond i04-1 fragment screening]]
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[[Category: Xchemexplorer]]
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Current revision

Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102660

PDB ID 5qiw

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