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6div

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Current revision (06:07, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6div' size='340' side='right'caption='[[6div]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
<StructureSection load='6div' size='340' side='right'caption='[[6div]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6div]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hepc 9hepc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6div]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DIV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methylcyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6div FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6div OCA], [http://pdbe.org/6div PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6div RCSB], [http://www.ebi.ac.uk/pdbsum/6div PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6div ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GKA:(2R,6S,12Z,13aS,14aR,16aS)-6-[(N-acetyl-3-methyl-L-valyl)amino]-2-[(7-methoxy-3-methylquinoxalin-2-yl)oxy]-N-[(1-methyl+cyclopropyl)sulfonyl]-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diaz+acyclopentadecine-14a(5H)-carboxamide'>GKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6div FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6div OCA], [https://pdbe.org/6div PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6div RCSB], [https://www.ebi.ac.uk/pdbsum/6div PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6div ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0B4WYC6_9HEPC A0A0B4WYC6_9HEPC]
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepacivirus C]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Matthew, A N]]
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[[Category: Matthew AN]]
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[[Category: Schiffer, C A]]
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[[Category: Schiffer CA]]
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[[Category: Drug resistance]]
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[[Category: Hepatitis c virus]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Ns3/4a protease]]
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[[Category: Protease inhibitor]]
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Current revision

Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-2 (AJ-67)

PDB ID 6div

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