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| | <StructureSection load='1t5r' size='340' side='right'caption='[[1t5r]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='1t5r' size='340' side='right'caption='[[1t5r]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1t5r]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_phage_pvl Staphylococcus phage pvl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T5R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1t5r]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_phage_PVL Staphylococcus phage PVL]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T5R FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pvl|1pvl]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5r OCA], [http://pdbe.org/1t5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t5r RCSB], [http://www.ebi.ac.uk/pdbsum/1t5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5r ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t5r OCA], [https://pdbe.org/1t5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t5r RCSB], [https://www.ebi.ac.uk/pdbsum/1t5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t5r ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q783R1_9CAUD Q783R1_9CAUD] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Staphylococcus phage pvl]] | + | [[Category: Staphylococcus phage PVL]] |
| - | [[Category: Guillet, V]] | + | [[Category: Guillet V]] |
| - | [[Category: Keller, D]] | + | [[Category: Keller D]] |
| - | [[Category: Mourey, L]] | + | [[Category: Mourey L]] |
| - | [[Category: Prevost, G]] | + | [[Category: Prevost G]] |
| - | [[Category: Roblin, P]] | + | [[Category: Roblin P]] |
| - | [[Category: Bi-component leucotoxin]]
| + | |
| - | [[Category: Pore-forming toxin]]
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| - | [[Category: S component leucocidin]]
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| - | [[Category: Staphylococcus aureus]]
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| - | [[Category: Unknown function]]
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| Structural highlights
Function
Q783R1_9CAUD
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Staphylococcal leucocidins and gamma-hemolysins (leucotoxins) are bi-component toxins that form lytic transmembrane pores. Their cytotoxic activities require the synergistic association of a class S component and a class F component, produced as water-soluble monomers that form hetero-oligomeric membrane-associated complexes. Strains that produce the Panton-Valentine leucocidin are clinically associated with cutaneous lesions and community-acquired pneumonia. In a previous study, we determined the crystal structure of the F monomer from the Panton-Valentine leucocidin. To derive information on the second component of the leucotoxins, the x-ray structure of the S protein from the Panton-Valentine leucocidin was solved to 2.0 angstrom resolution using a tetragonal crystal form that contains eight molecules in the asymmetric unit. The structure demonstrates the different conformation of the domain involved in membrane contacts and illustrates sequence and tertiary structure variabilities of the pore-forming leucotoxins. Mutagenesis studies at a key surface residue (Thr-28) further support the important role played by these microheterogeneities for the assembly of the bipartite leucotoxins.
Crystal structure of leucotoxin S component: new insight into the Staphylococcal beta-barrel pore-forming toxins.,Guillet V, Roblin P, Werner S, Coraiola M, Menestrina G, Monteil H, Prevost G, Mourey L J Biol Chem. 2004 Sep 24;279(39):41028-37. Epub 2004 Jul 18. PMID:15262988[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Guillet V, Roblin P, Werner S, Coraiola M, Menestrina G, Monteil H, Prevost G, Mourey L. Crystal structure of leucotoxin S component: new insight into the Staphylococcal beta-barrel pore-forming toxins. J Biol Chem. 2004 Sep 24;279(39):41028-37. Epub 2004 Jul 18. PMID:15262988 doi:10.1074/jbc.M406904200
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