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| | <StructureSection load='1sn2' size='340' side='right'caption='[[1sn2]], [[Resolution|resolution]] 1.75Å' scene=''> | | <StructureSection load='1sn2' size='340' side='right'caption='[[1sn2]], [[Resolution|resolution]] 1.75Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1sn2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Aurata_aurata Aurata aurata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SN2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1sn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sparus_aurata Sparus aurata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SN2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn0|1sn0]], [[1sn5|1sn5]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sn2 OCA], [http://pdbe.org/1sn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sn2 RCSB], [http://www.ebi.ac.uk/pdbsum/1sn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sn2 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sn2 OCA], [https://pdbe.org/1sn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sn2 RCSB], [https://www.ebi.ac.uk/pdbsum/1sn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sn2 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q9PTT3_SPAAU Q9PTT3_SPAAU] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | ==See Also== | | ==See Also== |
| - | *[[Transthyretin|Transthyretin]] | + | *[[Transthyretin 3D structures|Transthyretin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Aurata aurata]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cantos, C R]] | + | [[Category: Sparus aurata]] |
| - | [[Category: Eneqvist, T]] | + | [[Category: Cantos CR]] |
| - | [[Category: Huang, S]] | + | [[Category: Eneqvist T]] |
| - | [[Category: Karlsson, A]] | + | [[Category: Huang S]] |
| - | [[Category: Lundberg, E]] | + | [[Category: Karlsson A]] |
| - | [[Category: Power, D M]] | + | [[Category: Lundberg E]] |
| - | [[Category: Sauer-Eriksson, A E]] | + | [[Category: Power DM]] |
| - | [[Category: Transport protein]]
| + | [[Category: Sauer-Eriksson AE]] |
| Structural highlights
Function
Q9PTT3_SPAAU
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Transthyretin (TTR) is an extracellular transport protein involved in the distribution of thyroid hormones and vitamin A. So far, TTR has only been found in vertebrates, of which piscine TTR displays the lowest sequence identity with human TTR (47%). Human and piscine TTR bind both thyroid hormones 3,5,3'-triiodo-l-thyronine (T(3)) and 3,5,3',5'-tetraiodo-l-thyronine (thyroxine, T(4)). Human TTR has higher affinity for T(4) than T(3), whereas the reverse holds for piscine TTR. X-ray structures of Sparus aurata (sea bream) TTR have been determined as the apo-protein at 1.75 A resolution and bound to ligands T(3) and T(4), both at 1.9 A resolution. The apo structure is similar to human TTR with structural changes only at beta-strand D. This strand forms an extended loop conformation similar to the one in chicken TTR. The piscine TTR.T(4) complex shows the T(4)-binding site to be similar but not identical to human TTR, whereas the TTR.T(3) complex shows the I3' halogen situated at the site normally occupied by the hydroxyl group of T(4). The significantly wider entrance of the hormone-binding channel in sea bream TTR, in combination with its narrower cavity, provides a structural explanation for the different binding affinities of human and piscine TTR to T(3) and T(4).
High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.,Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. PMID:15082720[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Eneqvist T, Lundberg E, Karlsson A, Huang S, Santos CR, Power DM, Sauer-Eriksson AE. High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine. J Biol Chem. 2004 Jun 18;279(25):26411-6. Epub 2004 Apr 13. PMID:15082720 doi:10.1074/jbc.M313553200
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