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1t2r

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==Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain==
==Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain==
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<StructureSection load='1t2r' size='340' side='right'caption='[[1t2r]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='1t2r' size='340' side='right'caption='[[1t2r]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1t2r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T2R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1t2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T2R FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1t2s|1t2s]], [[1upo|1upo]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2r OCA], [http://pdbe.org/1t2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1t2r RCSB], [http://www.ebi.ac.uk/pdbsum/1t2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2r OCA], [https://pdbe.org/1t2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t2r RCSB], [https://www.ebi.ac.uk/pdbsum/1t2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t2r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME]] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>
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[https://www.uniprot.org/uniprot/AGO2_DROME AGO2_DROME] Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger.<ref>PMID:11498593</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Izaurralde, E]]
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[[Category: Izaurralde E]]
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[[Category: Lingel, A]]
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[[Category: Lingel A]]
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[[Category: Sattler, M]]
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[[Category: Sattler M]]
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[[Category: Simon, B]]
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[[Category: Simon B]]
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[[Category: Nucleic acid binding protein]]
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[[Category: Nucleic acid binding protein-rna complex]]
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[[Category: Rna]]
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Structural basis for 3' end recognition of nucleic acids by the Drosophila Argonaute 2 PAZ domain

PDB ID 1t2r

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