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5izq

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Current revision (10:40, 6 September 2023) (edit) (undo)
 
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<StructureSection load='5izq' size='340' side='right'caption='[[5izq]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
<StructureSection load='5izq' size='340' side='right'caption='[[5izq]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5izq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IZQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5izq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IZQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83A:N-(4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZENE-1-CARBONYL)-L-GLUTAMIC+ACID'>83A</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOLR1, FOLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=83A:N-(4-{[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)ETHYL]AMINO}BENZENE-1-CARBONYL)-L-GLUTAMIC+ACID'>83A</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izq OCA], [http://pdbe.org/5izq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5izq RCSB], [http://www.ebi.ac.uk/pdbsum/5izq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5izq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5izq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5izq OCA], [https://pdbe.org/5izq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5izq RCSB], [https://www.ebi.ac.uk/pdbsum/5izq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5izq ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[https://omim.org/entry/613068 613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
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[https://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brunzelle, J S]]
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[[Category: Brunzelle JS]]
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[[Category: Gu, X]]
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[[Category: Gu X]]
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[[Category: Ke, J]]
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[[Category: Ke J]]
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[[Category: Melcher, K]]
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[[Category: Melcher K]]
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[[Category: Xu, H E]]
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[[Category: Xu HE]]
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[[Category: Antifolate]]
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[[Category: Folate receptor alpha]]
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[[Category: Signaling protein]]
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[[Category: Tumor targeting]]
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Current revision

Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183

PDB ID 5izq

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OCA

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