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1udt

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<StructureSection load='1udt' size='340' side='right'caption='[[1udt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1udt' size='340' side='right'caption='[[1udt]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1udt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UDT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1udt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VIA:5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>VIA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1udu|1udu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VIA:5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE'>VIA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udt OCA], [https://pdbe.org/1udt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udt RCSB], [https://www.ebi.ac.uk/pdbsum/1udt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1udt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udt OCA], [http://pdbe.org/1udt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1udt RCSB], [http://www.ebi.ac.uk/pdbsum/1udt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1udt ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
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[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cho, J M]]
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[[Category: Cho JM]]
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[[Category: Eum, S J]]
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[[Category: Eum SJ]]
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[[Category: Heo, Y S]]
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[[Category: Heo Y-S]]
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[[Category: Hwang, K Y]]
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[[Category: Hwang KY]]
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[[Category: Hyun, Y L]]
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[[Category: Hyun Y-L]]
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[[Category: Jeon, Y H]]
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[[Category: Jeon YH]]
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[[Category: Kim, E]]
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[[Category: Kim E]]
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[[Category: Kim, J H]]
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[[Category: Kim JH]]
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[[Category: Lee, J I]]
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[[Category: Lee J-O]]
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[[Category: Lee, J O]]
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[[Category: Lee JI]]
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[[Category: Lee, T G]]
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[[Category: Lee TG]]
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[[Category: Moon, J]]
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[[Category: Moon J]]
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[[Category: Park, S Y]]
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[[Category: Park S-Y]]
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[[Category: Ro, S]]
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[[Category: Ro S]]
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[[Category: Sung, B J]]
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[[Category: Sung B-J]]
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[[Category: Yoon, J M]]
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[[Category: Yoon JM]]
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[[Category: Cgmp-specific phosphodiesterase 5]]
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[[Category: Hydrolase]]
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[[Category: Selective inhibitor]]
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[[Category: Sildenafil]]
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Current revision

Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)

PDB ID 1udt

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