Carbonic Anhydrase IX With Saccharin
From Proteopedia
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==Description/Function== | ==Description/Function== | ||
| - | Human '''carbonic anydrase 2''' is a one chain structure that is 260 amino acids long. It is a transmembrane homodimeric enzyme with an extracellularly positioned catalytic domain. 4RIU's functions include bone resorption, regulation of fluid secretion into anterior chamber of eye and catalyzing the hydration of CO2 to HCO3− and a proton. | + | Human '''carbonic anydrase 2''' is a one chain structure that is 260 amino acids long. It is a transmembrane homodimeric enzyme with an extracellularly positioned catalytic domain. 4RIU's functions include bone resorption, regulation of fluid secretion into anterior chamber of eye and catalyzing the hydration of CO2 to HCO3− and a proton. See also [[Carbonic anhydrase]]. |
==Abbreviations== | ==Abbreviations== | ||
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==Critical Amino Acids== | ==Critical Amino Acids== | ||
| - | <scene name='55/559112/Leu_91/1'>Leu 91</scene> | + | *<scene name='55/559112/Leu_91/1'>Leu 91</scene> |
| - | <scene name='55/559112/Leu_198/1'>Leu 198</scene> | + | *<scene name='55/559112/Leu_198/1'>Leu 198</scene> |
| - | <scene name='55/559112/Val_131/2'>Val 131</scene> | + | *<scene name='55/559112/Val_131/2'>Val 131</scene> |
</StructureSection> | </StructureSection> | ||
==References== | ==References== | ||
Current revision
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References
Brian P. Mahon, Alex M. Hendon, Jenna M. Driscoll, Gregory M. Rankin, Sally-Ann Poulsen, Claudiu T. Supuran, Robert McKenna, Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors, Bioorganic & Medicinal Chemistry, Volume 23, Issue 4, 15 February 2015, Pages 849-854, ISSN 0968-0896, http://dx.doi.org/10.1016/j.bmc.2014.12.030. (http://www.sciencedirect.com/science/article/pii/S0968089614008785)
Authors
Elizabeth A. Dunlap, Preeti K. Deol
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Elizabeth A. Dunlap, Michal Harel, Jaime Prilusky
