This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6tnc
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 46== | |
| + | <StructureSection load='6tnc' size='340' side='right'caption='[[6tnc]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6tnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=O23:N-CYCLOPROPYL-4-{8-[(THIOPHEN-2-YLMETHYL)AMINO]IMIDAZO[1,2-A]PYRAZIN-3-YL}BENZAMIDE'>O23</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnc OCA], [https://pdbe.org/6tnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tnc RCSB], [https://www.ebi.ac.uk/pdbsum/6tnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnc ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bader B]] | ||
| + | [[Category: Boemer U]] | ||
| + | [[Category: Bohlmann R]] | ||
| + | [[Category: Brands M]] | ||
| + | [[Category: Briem H]] | ||
| + | [[Category: Eberspaecher U]] | ||
| + | [[Category: Fernandez-Montalvan A]] | ||
| + | [[Category: Holton SJ]] | ||
| + | [[Category: Klar U]] | ||
| + | [[Category: Koppitz M]] | ||
| + | [[Category: Kosemund D]] | ||
| + | [[Category: Marquardt T]] | ||
| + | [[Category: Nguyen D]] | ||
| + | [[Category: Nussbaum F]] | ||
| + | [[Category: Prechtl S]] | ||
| + | [[Category: Schirok H]] | ||
| + | [[Category: Schulze VK]] | ||
| + | [[Category: Siemeister G]] | ||
Current revision
X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 46
| |||||||||||
Categories: Homo sapiens | Large Structures | Bader B | Boemer U | Bohlmann R | Brands M | Briem H | Eberspaecher U | Fernandez-Montalvan A | Holton SJ | Klar U | Koppitz M | Kosemund D | Marquardt T | Nguyen D | Nussbaum F | Prechtl S | Schirok H | Schulze VK | Siemeister G
