5upv
From Proteopedia
(Difference between revisions)
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<StructureSection load='5upv' size='340' side='right'caption='[[5upv]], [[Resolution|resolution]] 1.63Å' scene=''> | <StructureSection load='5upv' size='340' side='right'caption='[[5upv]], [[Resolution|resolution]] 1.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5upv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5upv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UPV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8KV:N-{(1S)-1-[3-METHOXY-4-(1,3-OXAZOL-5-YL)PHENYL]ETHYL}-N-PHENYLUREA'>8KV</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5upv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5upv OCA], [https://pdbe.org/5upv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5upv RCSB], [https://www.ebi.ac.uk/pdbsum/5upv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5upv ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: IMP dehydrogenase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: Anderson | + | [[Category: Anderson WF]] |
| - | + | [[Category: Gu M]] | |
| - | [[Category: Gu | + | [[Category: Joachimiak A]] |
| - | [[Category: Joachimiak | + | [[Category: Kim Y]] |
| - | [[Category: Kim | + | [[Category: Makowska-Grzyska M]] |
| - | [[Category: Makowska-Grzyska | + | [[Category: Maltseva N]] |
| - | [[Category: Maltseva | + | [[Category: Mulligan R]] |
| - | [[Category: Mulligan | + | |
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Current revision
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36
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